Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population

被引：58

作者：

Boonyaphiphat, P ^{[1
]}

Thongsuksai, P

Sriplung, H

Puttawibul, P

机构：

[1] Prince Songkla Univ, Fac Med, Dept Pathol, Hat Yai 90110, Thailand

[2] Prince Songkla Univ, Fac Med, Dept Surg, Hat Yai 90110, Thailand

来源：

CANCER LETTERS | 2002年 / 186卷 / 02期

关键词：

esophageal carcinoma; ADH2; ALDH2; genetic polymorphism; Thailand;

D O I：

10.1016/S0304-3835(02)00354-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The association of lifestyle habits and polymorphism of ADH2 and ALDH2 genes with the risk of esophageal cancer in Thai population was investigated in a hospital-based case-control study: 202 cases and 261 controls. The results of multivariate logistic analysis showed that alcohol consumption >60 g/day, smoking >10 cigarettes/day and chewing betel greater than or equal to10 quids/day significantly increased risk (odds ratio (OR) 5.84, 95% confidence interval (0) 3.15-10.83; 4.65, 95% CI 1.99-10.84; and 4.68, 95% CI 2.05-10.72, respectively). ADH2*1/*1 also increased the risk significantly (OR 1.56, 95% Cl 1.01-2.39) while ALDH2 did not (OR of ALDH2*1/*2 1.57,95% CI 0.89-2.76). However, the combined at risk genotypes, ADH2*1/*1 and ALDH2*1/*2 increased risk to four-fold. In addition, significant gene-environment interaction was found. Heavy drinkers >60 g/d harboring ADH2*1/*1 or ALDH2*1/*2 had about an 11-fold increased risk. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：193 / 199

页数：7

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