Site-3 sea anemone toxins: Molecular probes of gating mechanisms in voltage-dependent sodium channels

被引：43

作者：

Smith, Jaime J. ^{[1
]}

Blumenthal, Kenneth M. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Biochem, Sch Med & Biomed Sci, Buffalo, NY 14214 USA

来源：

TOXICON | 2007年 / 49卷 / 02期

关键词：

anemone toxin; scorpion toxin; sodium channel inactivation; voltage sensing; positive inotropic agents;

D O I：

10.1016/j.toxicon.2006.09.020

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sea anemone toxins, whose biological function is the capture of marine prey, are invaluable tools for studying the structure and function of mammalian voltage-gated sodium channels. Their high degree of specificity and selectivity have allowed for detailed analysis of inactivation gating and assignment of molecular entities responsible for this process. Because of their ability to discriminate among channel isoforms, and their high degree of structural conservation, these toxins could serve as important lead compounds for future pharmaceutical design. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：159 / 170

页数：12

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