Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children

被引:109
作者
Barlan, IB [1 ]
Erkan, E [1 ]
Bakir, M [1 ]
Berrak, S [1 ]
Basaran, MM [1 ]
机构
[1] MARMARA UNIV HOSP, DEPT PEDIAT, DIV PEDIAT ALLERGY IMMUNOL, ISTANBUL, TURKEY
关键词
D O I
10.1016/S1081-1206(10)63223-1
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: The role of topical corticosteroids in the treatment of acute sinusitis has not been established in children. Objective: An attempt was made to determine the impact of topical corticosteroids as an adjunct to antibiotic treatment in the management of childhood sinusitis. Methods: In a double-blind, placebo-controlled study. 151 children with sinusitis were recruited from a general pediatric outpatient clinic and 89 completed a 3-week trial. Treatment consisted of amoxicillin-clavulanate potassium, 40 mg/kg/d tid. combined with bid nasal spray of either budesonide, 50 mu g, to each nostril (n = 43) or placebo in = 46) for 3 weeks. Patients maintained daily symptom cards throughout the study and were examined by the same physician each week. Results: Clinical symptoms and signs decreased significantly in both treatment groups in comparison to baseline (P < .01). We detected a significant improvement in the scores of the cough and nasal discharge at the end of second week in the budesonide group when compared with placebo (P < .05). Friedman nonparametric repeated measures ANOVA test revealed a significant decrease in the total weekly scores of cough during the second week of budesonide treatment (P < .001) in contrast to continuous decline during the second and third weeks in the placebo group (P < .001 and P < .05, respectively). While the nasal discharge score decreased significantly during the second week in the budesonide group (P < .01), no significant effect on the nasal discharge score was observed in the placebo group. Conclusion: These data suggest that topical corticosteroids may be a useful ancillary treatment to antibiotics in childhood sinusitis and effective in reducing the cough and nasal discharge earlier in the course of acute sinusitis.
引用
收藏
页码:598 / 601
页数:4
相关论文
共 14 条
[1]   EFFICACY OF ENDONASAL NEOMYCIN-TIXOCORTOL PIVALATE IRRIGATION IN THE TREATMENT OF CHRONIC ALLERGIC AND BACTERIAL SINUSITIS [J].
CUENANT, G ;
STIPON, JP ;
PLANTELONGCHAMP, G ;
BAUDOIN, C ;
GUERRIER, Y .
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, 1986, 48 (04) :226-232
[2]  
DRETTNER B, 1988, ACTA OTO-LARYNGOL, P13
[3]   ADJUNCTS TO MEDICAL-MANAGEMENT OF SINUSITIS [J].
DRUCE, HM .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1990, 103 (05) :880-883
[4]   THE INVITRO AND INVIVO EFFECT OF A NEW NONHALOGENATED CORTICOSTEROID BUDESONIDE AEROSOL ON HUMAN CILIARY EPITHELIAL FUNCTION [J].
DUCHATEAU, GSMJE ;
ZUIDEMA, J ;
MERKUS, FWHM .
ALLERGY, 1986, 41 (04) :260-265
[5]   INFLUENCE OF TOPICAL BECLOMETHASONE DIPROPIONATE SUSPENSION ON HUMAN NASAL MUCOCILIARY ACTIVITY [J].
HOLMBERG, K ;
PIPKORN, U .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 30 (05) :625-627
[6]   INTRANASAL FLUNISOLIDE SPRAY AS AN ADJUNCT TO ORAL ANTIBIOTIC-THERAPY FOR SINUSITIS [J].
MELTZER, EO ;
ORGEL, HA ;
BACKHAUS, JW ;
BUSSE, WW ;
DRUCE, HM ;
METZGER, WJ ;
MITCHELL, DQ ;
SELNER, JC ;
SHAPIRO, GG ;
VANBAVEL, JH ;
BASCH, C .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1993, 92 (06) :812-823
[7]  
Messerklinger W, 1967, Acta Otolaryngol, V63, P176, DOI 10.3109/00016486709128748
[8]   ALLERGIC AND NON-ALLERGIC RHINITIS - THEIR CHARACTERIZATION WITH ATTENTION TO THE MEANING OF NASAL EOSINOPHILIA [J].
MULLARKEY, MF ;
HILL, JS ;
WEBB, DR .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1980, 65 (02) :122-126
[9]  
PATOW CA, 1983, EAR NOSE THROAT J, V62, P14
[10]   INHIBITION OF MEDIATOR RELEASE IN ALLERGIC RHINITIS BY PRETREATMENT WITH TOPICAL GLUCOCORTICOSTEROIDS [J].
PIPKORN, U ;
PROUD, D ;
LICHTENSTEIN, LM ;
KAGEYSOBOTKA, A ;
NORMAN, PS ;
NACLERIO, RM .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (24) :1506-1510