Regulation of immune tolerance by anti-inflammatory neuropeptides

被引：183

作者：

Gonzalez-Rey, Elena

Chorny, Alejo

Delgado, Mario

机构：

[1] CSIC, Inst Parasitol & Biomed, Granada 18100, Spain

[2] Univ Seville, Dept Bioquim Med & Biol Mol, E-41009 Seville, Spain

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1984

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The induction of antigen-specific tolerance is essential to maintain immune homeostasis, control autoreactive T cells, prevent the onset of autoimmune diseases and achieve tolerance of transplants. Inflammation is a necessary process for eliminating pathogens, but can lead to serious deleterious effects in the host if left unchecked. Identifying the endogenous factors that control immune tolerance and inflammation is a key goal in the field of immunology. In the last decade, various neuropeptides that are produced by immune cells with potent anti-inflammatory actions were found to participate in the maintenance of tolerance in different immunological disorders.

引用

收藏

页码：52 / 63

页数：12

相关论文

共 109 条

[1] Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease [J].

Abad, C ;

Martinez, C ;

Juarranz, MG ;

Arranz, A ;

Leceta, J ;

Delgado, M ;

Gomariz, RP .

GASTROENTEROLOGY, 2003, 124 (04) :961-971

[2] Melanocortin receptors: their functions and regulation by physiological agonists and antagonists [J].

Abdel-Malek, ZA .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2001, 58 (03) :434-441

[3] Corticotropin-releasing hormone augments proinflammatory cytokine production from macrophages in vitro and in lipopolysaccharide-induced endotoxin shock in mice [J].

Agelaki, S ;

Tsatsanis, C ;

Gravanis, A ;

Margioris, AN .

INFECTION AND IMMUNITY, 2002, 70 (11) :6068-6074

[4] Corticosteroid-independent inhibition of tumor necrosis factor production by the neuropeptide urocortin [J].

Agnello, D ;

Bertini, R ;

Sacco, S ;

Meazza, C ;

Villa, P ;

Ghezzi, P .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1998, 275 (05) :E757-E762

[5] MC1 receptors are constitutively expressed on leucocyte subpopulations with antigen presenting and cytotoxic functions [J].

Andersen, GN ;

Nagaeva, O ;

Mandrika, I ;

Petrovska, R ;

Muceniece, R ;

Mincheva-Nilsson, L ;

Wikberg, JES .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2001, 126 (03) :441-446

[6] Relationship between circulating levels of calcitonin gene-related peptide, nitric oxide metabolites and hemodynamic changes in human septic shock [J].

Arnalich, F ;

Hernanz, A ;

Jimenez, M ;

Lopez, J ;

Tato, E ;

Vazquez, JJ ;

Montiel, C .

REGULATORY PEPTIDES, 1996, 65 (02) :115-121

[7] VIPase autoantibodies in Fas-defective mice and patients with autoimmune disease [J].

Bangale, Y ;

Karle, S ;

Planque, S ;

Zhou, YX ;

Taguchi, H ;

Nishiyama, Y ;

Li, L ;

Kalaga, R ;

Paul, S .

FASEB JOURNAL, 2003, 17 (06) :628-635

[8]

Becher E, 1999, ANN NY ACAD SCI, V885, P188

[9] Vasoactive intestinal polypeptide (VIP) innervation of rat spleen, thymus, and lymph nodes [J].

Bellinger, DL ;

Lorton, D ;

Horn, L ;

Brouxhon, S ;

Felten, SY ;

Felten, DL .

PEPTIDES, 1997, 18 (08) :1139-1149

[10]

Bhardwaj RS, 1996, J IMMUNOL, V156, P2517

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