Regulation of gene expression by oxygen:: NF-κB and HIF-1, two extremes

被引：171

作者：

Michiels, C ^{[1
]}

Minet, E ^{[1
]}

Mottet, D ^{[1
]}

Raes, M ^{[1
]}

机构：

[1] Univ Namur, FUNDP, Lab Biochim & Biol Cellulaire, B-5000 Namur, Belgium

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2002年 / 33卷 / 09期

关键词：

NF-kappa B; hypoxia-inducible factor-1; reactive oxygen species; hypoxia; oxygen sensor; protein kinases; proteasome; free radicals;

D O I：

10.1016/S0891-5849(02)01045-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aerobic life is dependent on molecular oxygen for ATP regeneration, but only possible in a narrow range of oxygen concentrations. Increased oxygen tension is toxic through the generation of reactive oxygen species (ROS), while a decrease in oxygen concentration impairs energy availability and, hence, cell viability. Cells have developed strategies to respond to changes in oxygen tension: specific systems detect excessive ROS and hypoxia, leading to the activation of specific transcription factors and expression of appropriate target genes. The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-kappaB (NF-kappaB) are regulated and what could be the sensors to the changes in oxygen levels. Some of the physiological responses initiated by these transcription factors are also mentioned. (C) 2002 Elsevier Science Inc.

引用

页码：1231 / 1242

页数：12

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