Plakophilins: multifunctional scaffolds for adhesion and signaling

被引：132

作者：

Bass-Zubek, Amanda E. ^{[1
]}

Godsel, Lisa M. ^{[1
,2
]}

Delmar, Mario ^{[3
]}

Green, Kathleen J. ^{[1
,2
]}

机构：

[1] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Dermatol, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Univ Michigan, Ctr Arrhythmia Res, Div Cardiovasc Med, Ann Arbor, MI 48108 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 05期

基金：

美国国家卫生研究院;

关键词：

RIGHT-VENTRICULAR CARDIOMYOPATHY; HEART-MUSCLE CELLS; PROTEIN-KINASE-C; DESMOSOMAL PLAQUE; EPITHELIAL-CELLS; ADHERENS JUNCTIONS; AREA-COMPOSITA; ARMADILLO PROTEIN; P120; CATENIN; DESMOPLAKIN;

D O I：

10.1016/j.ceb.2009.07.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Armadillo family proteins known as plakophilins have been characterized as structural components of desmosomes that stabilize and strengthen adhesion by enhancing attachments with the intermediate filament cytoskeleton. However, plakophilins and their close relatives are emerging as versatile scaffolds for multiple signaling and metabolic processes that not only facilitate junction dynamics but also more globally regulate diverse cellular activities. While perturbation of plakophilin functions contribute to inherited diseases and cancer pathogenesis, the functional significance of the multiple PKP isoforms and the mechanisms by which their behaviors are regulated remain to be elucidated.

引用

页码：708 / 716

页数：9

共 67 条

[1]

The transcription factor ZEB1 (δEF1) represses Plakophilin 3 during human cancer progression [J].

Aigner, Kirsten ;

Descovich, Luise ;

Mikula, Mario ;

Sultan, Aneesa ;

Dampier, Brigitta ;

Bonne, Stefan ;

van Roy, Frans ;

Mikulits, Wolfgang ;

Schreiber, Martin ;

Brabletz, Thomas ;

Sommergruber, Wolfgang ;

Schweifer, Norbert ;

Wernitznig, Andreas ;

Beug, Hartmut ;

Foisner, Roland ;

Eger, Andreas .

FEBS LETTERS, 2007, 581 (08) :1617-1624

[2]

p120-ctn: A nexus for contextual signaling via Rho GTPases [J].

Anastasiadis, Panos Z. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2007, 1773 (01) :34-46

[3]

A New Diagnostic Test for Arrhythmogenic Right Ventricular Cardiomyopathy. [J].

Asimaki, Angeliki ;

Tandri, Harikrishna ;

Huang, Hayden ;

Halushka, Marc K. ;

Gautam, Shiva ;

Basso, Cristina ;

Thiene, Gaetano ;

Tsatsopoulou, Adalena ;

Protonotarios, Nikos ;

McKenna, William J. ;

Calkins, Hugh ;

Saffitz, Jeffrey E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (11) :1075-1084

[4]

Plakophilin 2:: a critical scaffold for PKCα that regulates intercellular junction assembly [J].

Bass-Zubek, Amanda E. ;

Hobbs, Ryan P. ;

Amargo, Evangeline V. ;

Garcia, Nicholas J. ;

Hsieh, Sherry N. ;

Chen, Xinyu ;

Wahl, James K., III ;

Denning, Mitchell F. ;

Green, Kathleen J. .

JOURNAL OF CELL BIOLOGY, 2008, 181 (04) :605-613

[5]

Defining desmosomal plakophilin-3 interactions [J].

Bonné, S ;

Gilbert, B ;

Hatzfeld, M ;

Chen, X ;

Green, KJ ;

van Roy, F .

JOURNAL OF CELL BIOLOGY, 2003, 161 (02) :403-416

[6]

Bonné S, 1999, J CELL SCI, V112, P2265

[7]

Bornslaeger EA, 2001, J CELL SCI, V114, P727

[8]

The armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein [J].

Calkins, CC ;

Hoepner, BL ;

Law, CM ;

Novak, MR ;

Setzer, SV ;

Hatzfeld, M ;

Kowalczyk, AP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1774-1783

[9]

Protein binding and functional characterization of plakophilin 2 -: Evidence for its diverse roles in desmosomes and β-catenin signaling [J].

Chen, XY ;

Bonné, S ;

Hatzfeld, M ;

van Roy, F ;

Green, KJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (12) :10512-10522

[10]

Structure of the armadillo repeat domain of plakophilin 1 [J].

Choi, HJ ;

Weis, WI .

JOURNAL OF MOLECULAR BIOLOGY, 2005, 346 (01) :367-376

← 1 2 3 4 5 6 7 →