Psoriasis: Behind the scenes

被引：46

作者：

Furue, Masutaka ^{[1
]}

Kadono, Takafumi ^{[2
]}

机构：

[1] Kyushu Univ, Dept Dermatol, Fukuoka 8128582, Japan

[2] St Marianna Univ, Sch Med, Dept Dermatol, Kawasaki, Kanagawa, Japan

来源：

JOURNAL OF DERMATOLOGY | 2016年 / 43卷 / 01期

关键词：

interleukin-17; interleukin-23; interleukin-36; gamma; psoriasis; tumor necrosis factor-alpha; GENERALIZED PUSTULAR PSORIASIS; ULTRAVIOLET-B PHOTOTHERAPY; FACTOR-ALPHA INHIBITOR; DELTA-T-CELLS; ALCOHOL-CONSUMPTION; PLAQUE PSORIASIS; KERATINOCYTE CROSSTALK; CARDIOVASCULAR-DISEASE; USTEKINUMAB TREATMENT; ADIPONECTIN LEVELS;

D O I：

10.1111/1346-8138.13186

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Psoriasis is a chronic inflammatory skin disease characterized by a significant deterioration in the quality of life of affected individuals. Notably, psoriasis is significantly associated with cardiovascular and metabolic syndrome and other autoimmune disorders. Recent progress in biologic therapies has revealed the fundamental role of tumor necrosis factor-alpha, interleukin (IL)-23 and the IL-17A axis together with aberrant overproduction of epidermal IL-36 gamma in the pathogenesis of psoriasis. This review provides an update on the clinical, pathological and therapeutic advancements involving psoriasis.

引用

页码：4 / 8

页数：5

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