Promoting angiogenesis to a fault

被引：8

作者：

Hicklin, Daniel J. ^{[1
]}

机构：

[1] ImClone Syst Inc, New York, NY 10014 USA

来源：

NATURE BIOTECHNOLOGY | 2007年 / 25卷 / 03期

关键词：

D O I：

10.1038/nbt0307-300

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Promoting angiogenesis - rather than blocking it - may represent a new strategy for killing tumors.

引用

页码：300 / 302

页数：4

共 12 条

[1] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[2] Dosage-sensitive requirement for mouse D114 in artery development [J].

Duarte, A ;

Hirashima, M ;

Benedito, R ;

Trindade, A ;

Diniz, P ;

Bekman, E ;

Costa, L ;

Henrique, D ;

Rossant, J .

GENES & DEVELOPMENT, 2004, 18 (20) :2474-2478

[3] Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development [J].

Gale, NW ;

Dominguez, MG ;

Noguera, I ;

Pan, L ;

Hughes, V ;

Valenzuela, DM ;

Murphy, AJ ;

Adams, NC ;

Lin, HC ;

Holash, J ;

Thurston, G ;

Yancopoulos, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (45) :15949-15954

[4] The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions [J].

Hainaud, Patricia ;

Contreres, Jean-Olivier ;

Villemain, Aude ;

Liu, Lang-Xia ;

Plouet, Jean ;

Tobelem, Gerard ;

Dupuy, Evelyne .

CANCER RESEARCH, 2006, 66 (17) :8501-8510

[5] Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis [J].

Hicklin, DJ ;

Ellis, LM .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (05) :1011-1027

[6] Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy [J].

Jain, RK .

SCIENCE, 2005, 307 (5706) :58-62

[7] Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants [J].

Krebs, LT ;

Shutter, JR ;

Tanigaki, K ;

Honjo, T ;

Stark, KL ;

Gridley, T .

GENES & DEVELOPMENT, 2004, 18 (20) :2469-2473

[8] sonic hedgehog and vascular endothelial growth factor act upstream of the notch pathway during arterial endothelial differentiation [J].

Lawson, ND ;

Vogel, AM ;

Weinstein, BM .

DEVELOPMENTAL CELL, 2002, 3 (01) :127-136

[9] Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis [J].

Noguera-Troise, Irene ;

Daly, Christopher ;

Papadopoulos, Nicholas J. ;

Coetzee, Sandra ;

Boland, Pat ;

Gale, Nicholas W. ;

Lin, Hsin Chieh ;

Yancopoulos, George D. ;

Thurston, Gavin .

NATURE, 2006, 444 (7122) :1032-1037

[10] Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function [J].

Patel, NS ;

Li, JL ;

Generali, D ;

Poulsom, R ;

Cranston, DW ;

Harris, AL .

CANCER RESEARCH, 2005, 65 (19) :8690-8697

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