Trigochinins A-C: Three New Daphnane-Type Diterpenes from Trigonostemon chinensis

被引：47

作者：

Chen, Hua-Dong ^{[1
]}

Yang, Sheng-Ping ^{[1
]}

He, Xiu-Feng ^{[1
]}

Ai, Jing ^{[1
]}

Liu, Zhen-Kai ^{[1
]}

Liu, Hong-Bing ^{[1
]}

Geng, Mei-Yu ^{[1
]}

Yue, Jian-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 06期

关键词：

RECEPTOR TYROSINE KINASE; REIDIOIDES; POTENT; PLANT; MET; INHIBITORS; REDIOCIDE; GROWTH; ROOTS;

D O I：

10.1021/ol9028995

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three highly oxygenated new diterpenes, trigochinins A-C (1-3) were isolated from Trigonostemon chinensis. Their structures with the absolute configuration were determined by a spectroscopic method, X-ray crystallography, and CD analysis. This study suggested the revision of the C-6 stereochemistry of trigonothyrins A-C reported quite recently. Compound 3 showed significant inhibition against MET tyrosine kinase activity with a IC50 value of 1.95 mu M.

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收藏

页码：1168 / 1171

页数：4

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