G-quadruplex structures: in vivo evidence and function

被引:673
作者
Lipps, Hans J. [1 ]
Rhodes, Daniela [2 ]
机构
[1] Univ Witten Herdecke, Inst Cell Biol, D-58448 Witten, Germany
[2] MRC, Mol Biol Lab, Cambridge CB2 0QH, England
基金
英国医学研究理事会;
关键词
TELOMERE-BINDING PROTEIN; DNA-DAMAGE RESPONSE; RNA G-QUADRUPLEX; WERNER-SYNDROME; HUMAN GENOME; SACCHAROMYCES-CEREVISIAE; CAENORHABDITIS-ELEGANS; EUKARYOTIC CELLS; CHROMOSOME ENDS; SMALL-MOLECULE;
D O I
10.1016/j.tcb.2009.05.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Although many biochemical and structural studies have demonstrated that DNA sequences containing runs of adjacent guanines spontaneously fold into G-quadruplex DNA structures in vitro, only recently has evidence started to accumulate for their presence and function in vivo. Genome-wide analyses have revealed that functional genomic regions from highly divergent organisms are enriched in DNA sequences with G-quadruplex-forming potential, suggesting that G-quadruplexes could provide a nucleic-acid-based mechanism for regulating telomere maintenance, as well as transcription, replication and translation. Here, we review recent studies aimed at uncovering the in vivo presence and function of G-quadruplexes in genomes and RNA, with a particular focus on telomeric G-quadruplexes and how their formation and resolution is regulated to permit telomere synthesis.
引用
收藏
页码:414 / 422
页数:9
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