Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists

被引：29

作者：

Fotouhi, N ^{[1
]}

Joshi, P ^{[1
]}

Tilley, JW ^{[1
]}

Rowan, K ^{[1
]}

Schwinge, V ^{[1
]}

Wolitzky, B ^{[1
]}

机构：

[1] Hoffmann La Roche Inc, Roche Res Ctr, Nutley, NJ 07110 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(00)00175-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependant on rin size and the position of the sulfur atom. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1167 / 1169

页数：3

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