Structure and function of pancreatic lipase and colipase

被引：98

作者：

Lowe, ME ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT MOL BIOL & PHARMACOL,ST LOUIS,MO 63110

来源：

ANNUAL REVIEW OF NUTRITION | 1997年 / 17卷

关键词：

pancreas; protein structure; triglycerides;

D O I：

10.1146/annurev.nutr.17.1.141

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Dietary fats are essential for life and good health. Efficient absorption of dietary fats is dependent on the action of pancreatic triglyceride lipase. In the last few years, large advances have been made in describing the structure and lipolytic mechanism of human pancreatic triglyceride lipase and of colipase, another pancreatic protein that interacts with pancreatic triglyceride lipase and that is required for lipase activity in the duodenum. This review discusses the advances made in protein structure and in understanding the relationships of structure to function of pancreatic triglyceride lipase and colipase.

引用

页码：141 / 158

页数：18

共 74 条

[1] LIPASES OF BLOOD AND TISSUES .3. PURIFICATION AND PROPERTIES OF PANCREATIC LIPASE [J].

BASKYS, B ;

KLEIN, E ;

LEVER, WF .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1963, 102 (02) :201-&

[2]

BORGSTRO.B, 1971, BIOCHIM BIOPHYS ACTA, V242, P509

[3]

BORGSTROM B, 1984, LIPASES, P152

[4] A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX [J].

BRZOZOWSKI, AM ;

DEREWENDA, U ;

DEREWENDA, ZS ;

DODSON, GG ;

LAWSON, DM ;

TURKENBURG, JP ;

BJORKLING, F ;

HUGEJENSEN, B ;

PATKAR, SA ;

THIM, L .

NATURE, 1991, 351 (6326) :491-494

[5] SECRETION AND CONTRIBUTION TO LIPOLYSIS OF GASTRIC AND PANCREATIC LIPASES DURING A TEST MEAL IN HUMANS [J].

CARRIERE, F ;

BARROWMAN, JA ;

VERGER, R ;

LAUGIER, R .

GASTROENTEROLOGY, 1993, 105 (03) :876-888

[6] DIRECT INVOLVEMENT OF THE C-TERMINAL EXTREMITY OF PANCREATIC LIPASE (403-449) IN COLIPASE BINDING [J].

CHAILLAN, C ;

KERFELEC, B ;

FOGLIZZO, E ;

CHAPUS, C .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (01) :206-211

[7] MINIREVIEW ON PANCREATIC LIPASE AND COLIPASE [J].

CHAPUS, C ;

ROVERY, M ;

SARDA, L ;

VERGER, R .

BIOCHIMIE, 1988, 70 (09) :1223-1234

[8] THE LIPOPROTEIN LIPASE-ENCODING HUMAN GENE - SEQUENCE FROM INTRON-6 TO INTRON-9 AND PRESENCE IN INTRON-7 OF A 40-MILLION-YEAR-OLD ALU SEQUENCE [J].

CHUAT, JC ;

RAISONNIER, A ;

ETIENNE, J ;

GALIBERT, F .

GENE, 1992, 110 (02) :257-261

[9]

CYGLER M, 1993, PROTEIN SCI, V2, P366

[10] HUMAN PANCREATIC LIPASE - GLYCOPROTEIN [J].

DECARO, A ;

FIGARELLA, C ;

AMIC, J ;

MICHEL, R ;

GUY, O .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 490 (02) :411-419

← 1 2 3 4 5 6 7 8 →