Antiviral activity of berberine and related compounds against human cytomegalovirus

被引：150

作者：

Hayashi, Kyoko

Minoda, Kazuki

Nagaoka, Yasuo

Hayashi, Toshimitsu

Uesato, Shinichi

机构：

[1] Kansai Univ, Fac Engn, Dept Biotechnol, Suita, Osaka 5648680, Japan

[2] Kansai Univ, High Technol Res Ctr, Suita, Osaka 5648680, Japan

[3] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Sugitani, Toyama 9300194, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 06期

关键词：

berberine; papaverine; ganciclovir; human cytomegalovirus;

D O I：

10.1016/j.bmcl.2006.12.085

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus ;(HCMV) activity using the plaque assay. The anti-HCMV activity (IC50 0.68 mu M) of 1 was equivalent to that (IC50 0.91 mu m) of ganciclovir (GCV). The mechanism of action by which I inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis. (c) 2007 Elsevier Ltd. All rights reserved.

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页码：1562 / 1564

页数：3

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