Integrating cell-signalling pathways with NF-κB and IKK function

被引：1970

作者：

Perkins, Neil D. ^{[1
]}

机构：

[1] Univ Dundee, Coll Life Sci, Div Gene Regulat & Express, James Black Ctr, Dundee DD1 5EH, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrm2083

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear factor (NF)-kappa B and inhibitor of NF-kappa B kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-kappa B or IKK function contributes to many human diseases, including cancer. However, the NF-kappa B and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-kappa B and IKK activation and, ultimately, cell fate.

引用

收藏

页码：49 / 62

页数：14

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