Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice

被引:54
作者
Wallace, TL
Paetznick, V
Cossum, PA
LopezBerestein, G
Rex, JH
Anaissie, E
机构
[1] UNIV TEXAS, SCH MED, HOUSTON, TX USA
[2] UNIV TEXAS, MD ANDERSON CANC CTR, HOUSTON, TX USA
关键词
D O I
10.1128/AAC.41.10.2238
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The purpose of this study was to examine the activity of liposomal nystatin against a disseminated Aspergillus fumigatus infection in neutropenic mice, Mice were made neutropenic with 5-fluorouracil and were administered the antifungal drug intravenously for 5 consecutive days beginning 24 h following infection, Liposomal nystatin, at doses as low as 2 mg/kg of body weight/day, protected neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50 day time point compared to either the no-treatment, the saline, or the empty-liposome group. This protection was approximately the same as that for free nystatin, a positive control, Histopathological results showed that liposomal nystatin cleared the lungs, spleen, pancreas, kidney, and liver of Aspergillus and that there was no organ damage at the day 5 time point, which was after only three doses of liposomal nystatin. Based on these results in mice, it is probable that liposomal nystatin will be effective against Aspergillus infection in humans.
引用
收藏
页码:2238 / 2243
页数:6
相关论文
共 58 条
[1]   COMPARISON OF THE INVITRO ANTIFUNGAL ACTIVITY OF FREE AND LIPOSOME-ENCAPSULATED AMPHOTERICIN-B [J].
ANAISSIE, E ;
PAETZNICK, V ;
PROFFITT, R ;
ADLERMOORE, J ;
BODEY, GP .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1991, 10 (08) :665-668
[2]   ANIMAL-MODELS - USEFULNESS FOR STUDIES OF FUNGAL PATHOGENESIS AND DRUG EFFICACY IN ASPERGILLOSIS [J].
ANDRIOLE, VT ;
MINITER, P ;
GEORGE, D ;
KORDICK, D ;
PATTERSON, TF .
CLINICAL INFECTIOUS DISEASES, 1992, 14 :S134-S138
[3]  
BENNETT JE, 1994, GOODMAN GILMANS PHAR, P1165
[4]  
BENNETT JE, 1994, HARRISONS PRINCIPLES, P854
[5]  
BOUTATI E, 1995, 35 INT C ANT AG CHEM, P330
[6]  
BROUGHTON MC, 1991, MYCOSES, V34, P75, DOI 10.1111/j.1439-0507.1991.tb00623.x
[7]   EFFECT OF FUNGICIDIN (NYSTATIN) IN MICE INJECTED WITH LETHAL MIXTURES OF AUREOMYCIN AND CANDIDA-ALBICANS [J].
BROWN, R ;
HAZEN, EL ;
MASON, A .
SCIENCE, 1953, 117 (3048) :609-610
[8]   PRIMARY CUTANEOUS ASPERGILLOSIS [J].
CAHILL, KM ;
ELMOFTY, AM ;
KAWAGUCHI, TP .
ARCHIVES OF DERMATOLOGY, 1967, 96 (05) :545-+
[9]  
CAMPBELL CC, 1955, ANTIBIOT ANNU, P858
[10]   DISSOCIATION BETWEEN ION PERMEABILITY AND LETHAL ACTION OF POLYENE ANTIBIOTICS ON CANDIDA-ALBICANS [J].
CHEN, WC ;
CHOU, DL ;
FEINGOLD, DS .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 13 (06) :914-917