Kinetic modeling of PET-FDG in the brain without blood sampling

被引：17

作者：

Bentourika, M'hamed ^{[1
]}

机构：

[1] Univ Sherbrooke, Dept Med Nucl & Radiobiol, Sherbrooke, PQ JIH 5N4, Canada

来源：

COMPUTERIZED MEDICAL IMAGING AND GRAPHICS | 2006年 / 30卷 / 08期

关键词：

positron emission tomography; fluorodeoxyglucose; brain; kinetic modeling; cerebral metabolic rates for glucose; input curve; blood sampling;

D O I：

10.1016/j.compmedimag.2006.07.002

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

The aim in this work is to report a new method to calculate parametric images from a single scan acquisition with positron emission tomography (PET) and fluorodeoxyglucose (FDG) in the human brain without blood sampling. It is usually practical for research or clinical purposes to inject the patient in an isolated room and to start the PET acquisition only for some 10-20 min, about 30 min after FDG injection. In order to calculate the cerebral metabolic rates for glucose (CMRG), usually several blood samples are required. The proposed method considers the relation between the uptake of the tracer in the cerebellum as a reference tissue and the population based input curve. Similar results were obtained for CMRG values with the present method in comparison to the usual autoradiographic and the non-linear least squares fitting of regions of interest. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：447 / 451

页数：5

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