Hemorrhagic hereditary telangiectasia (Rendu-Osler disease) and infectious diseases: An underestimated association

被引：67

作者：

Dupuis-Girod, Sophie

Giraud, Sophie

Decullier, Evelyne

Lesca, Gaetan

Cottin, Vincent

Faure, Frederic

Merrot, Olivier

Saurin, Jean-Christophe

Cordier, Jean-Francois

Plauchu, Henri

机构：

[1] Hop Hotel Dieu, Serv Genet, Hospices Civils Lyon, F-69288 Lyon 02, France

[2] Hop Hotel Dieu, Ctr Reference Malad Rendu Osler, F-69288 Lyon, France

[3] Hop Edouard Herriot, Genet Mol Lab, Lyon, France

[4] Hop Edouard Herriot, Serv Otorhinolaryngol, Lyon, France

[5] Hop Louis Pradel, Serv Pneumol, Lyon, France

[6] Hop Louis Pradel, Ctr Reference Malad Orphelines Pulm, Lyon, France

[7] Hop Croix Rousse, Serv Otorhinolaryngol, F-69317 Lyon, France

[8] Univ Lyon 1, Serv Hepatogastroenterol, Hop Lyon Sud, Hospices Civils Lyon, F-69365 Lyon, France

来源：

CLINICAL INFECTIOUS DISEASES | 2007年 / 44卷 / 06期

关键词：

D O I：

10.1086/511645

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among 353 patients with hereditary hemorrhagic telangiectasia retrospectively analyzed during the period 1985-2005, we identified 67 cases of severe infection that affected 48 patients (13.6%). Extracerebral infections accounted for 67% of all infections, and most involved Staphylococcus aureus and were associated with prolonged epistaxis. Cerebral infections accounted for 33% of all infections, were mainly due to multiple and anaerobic bacteria, and were associated with the presence of pulmonary arteriovenous malformations and a short duration of epistaxis.

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页码：841 / 845

页数：5

相关论文

共 23 条

[1] Bidirectional regulation of macrophage function by TGF-β [J].

Ashcroft, GS .

MICROBES AND INFECTION, 1999, 1 (15) :1275-1282

[2] Hereditary hemorrhagic telangectasia and spinal infection [J].

Blanco, P ;

Schaeverbeke, T ;

Baillet, L ;

Lequen, L ;

Bannwarth, B ;

Dehais, J .

REVUE DE MEDECINE INTERNE, 1998, 19 (12) :938-939

[3]

BLANCO P, 2005, 6 HHT SCI C LYON FRA, V54

[4] Doppler ultrasonographic grading of hepatic vascular malformations in hereditary hemorrhagic telangiectasia - Results of extensive screening [J].

Buscarini, E ;

Danesino, C ;

Olivieri, C ;

Lupinacci, G ;

De Grazia, F ;

Reduzzi, L ;

Blotta, P ;

Gazzaniga, P ;

Pagella, F ;

Grosso, M ;

Pongiglione, G ;

Buscarini, L ;

Plauchu, H ;

Zambelli, A .

ULTRASCHALL IN DER MEDIZIN, 2004, 25 (05) :348-355

[5] Patients with Hereditary Hemorrhagic Telangectasia (HHT) exhibit a deficit of polymorphonuclear cell and monocyte oxidative burst and phagocytosis:: A possible correlation with altered adaptive immune responsiveness in HHT [J].

Cirulli, Anna ;

Loria, Maria Paola ;

Dambra, Porzia ;

Di Serio, Francesca ;

Ventura, Maria T. ;

Amati, Luigi ;

Jirillo, Emilio ;

Sabba, Carlo .

CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (10) :1209-1215

[6] A new locus for hereditary haemorrhagic telangiectasia (HHT3) maps to chromosome 5 [J].

Cole, SG ;

Begbie, ME ;

Wallace, GMF ;

Shovlin, CL .

JOURNAL OF MEDICAL GENETICS, 2005, 42 (07) :577-582

[7] Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia [J].

Cottin, V ;

Plauchu, H ;

Bayle, JY ;

Barthelet, M ;

Revel, D ;

Cordier, JF .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 169 (09) :994-1000

[8] Epidemiology of sepsis: Recent advances [J].

Danai P. ;

Martin G.S. .

Current Infectious Disease Reports, 2005, 7 (5) :329-334

[9] TOXIC-SHOCK SYNDROME - EPIDEMIOLOGIC FEATURES, RECURRENCE, RISK-FACTORS, AND PREVENTION [J].

DAVIS, JP ;

CHESNEY, PJ ;

WAND, PJ ;

LAVENTURE, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1980, 303 (25) :1429-1435

[10] Recurrent Staphylococcus aureus extracerebral infections complicating hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) [J].

Duval, X ;

Djendli, S ;

Le Moing, V ;

Longuet, P ;

Barry, B ;

Leport, C ;

Vildé, JL .

AMERICAN JOURNAL OF MEDICINE, 2001, 110 (08) :671-672