Protein versus conventional crystals: Creation of defects

被引:41
作者
Chernov, AA
机构
[1] Universities Space Res. Assoc., NASA MSFC, Huntsville, AL 35806
关键词
kinetics of growth; solution growth; low temperature; superlattices;
D O I
10.1016/S0022-0248(96)01129-3
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
Recent data on protein crystal growth are reviewed and analyzed with an emphasis to crystal perfection. Since relative supersaturation for protein crystal growth is typically much higher than unity, no considerable detachment of species is expected once joined to the crystal lattice at a kink. Selection of proper molecules and their precise orientation should occur mainly at the stage when they try to join kinks. Sectorial and zonal (striation) structures induced by impurities and other point defects may cause mosaicity even without creation of misfit dislocations. Critical crystal size is estimated al which the dislocation network may be thermodynamically favorable. Since the crystals have isometric shape, this critical size turns out to be about an order of magnitude higher than the critical thickness of a pseudomorphic epitaxial layer. X-ray diffraction rocking curves width of about 0.02 degrees for reflections equivalent to a misfit similar to 3 x 10(-4) should correspond to the critical crystal of ca 0.5 mm, As in epitaxy, if nucleation and spread of dislocations are hindered, the critical size may be essentially bigger or the crystal should crack. At high impurity concentrations, new misoriented blocks may appear by surface nucleation, similar to what should happen in inorganic crystals growing from solutions.
引用
收藏
页码:354 / 361
页数:8
相关论文
共 67 条
  • [1] ALEXEEV IV, 1996, CRYSTALLOGR REP+, V41, P329
  • [2] [Anonymous], 1994, ACTA CRYSTALLOGR D, V50, P4
  • [3] Bauser E., 1994, HDB CRYSTAL GROWTH B, P879
  • [4] KDP AND DKDP CRYSTALS FOR NONLINEAR OPTICS GROWN AT HIGH-RATE
    BESPALOV, VI
    BREDIKHIN, VI
    ERSHOV, VP
    KATSMAN, VI
    LAVROV, LA
    [J]. JOURNAL OF CRYSTAL GROWTH, 1987, 82 (04) : 776 - 778
  • [5] BESPALOV VI, 1982, KVANTOVAYA ELEKTRON+, V9, P2343
  • [6] Experiments in microgravity: A comparison of crystals of a carbohydrate-binding fab grown on the ground, on space shuttle Discovery, and on space station Mir
    Borisova, SN
    Birnbaum, GI
    Rose, DR
    Evans, SV
    [J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1996, 52 : 267 - 271
  • [7] Cabrera N., 1958, GROWTH PERFECTION CR, P393
  • [8] Trends and challenges in experimental macromolecular crystallography
    Chayen, NE
    Boggon, TJ
    Cassetta, A
    Deacon, A
    Gleichmann, T
    Habash, J
    Harrop, SJ
    Helliwell, JR
    Nieh, YP
    Peterson, MR
    Raftery, J
    Snell, EH
    Hadener, A
    Niemann, AC
    Siddons, DP
    Stojanoff, V
    Thompson, AW
    Ursby, T
    Wulff, M
    [J]. QUARTERLY REVIEWS OF BIOPHYSICS, 1996, 29 (03) : 227 - 278
  • [9] Chernov A. A., 1986, Soviet Physics - Crystallography, V31, P705
  • [10] Chernov A. A., 1987, Soviet Physics - Crystallography, V32, P886