Cell surface receptors

被引:37
作者
Deller, MC
Jones, EY
机构
[1] Wellcome Trust Ctr Human Genet, CRC, Receptor Struct Grp, Oxford OX3 7BN, England
[2] Oxford Ctr Mol Sci, Oxford OX1 3QT, England
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0959-440X(00)00072-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During the past year, the database of ligand-receptor complexes has essentially doubled. These new results have immeasurably extended and expanded our view of cell surface receptor structure and function. The flood of data has revealed new modes for receptor cross-linking, demonstrating the potential stringency of the extracellular requirements for the initiation of intracellular signalling and highlighting unexpected interactions suggestive of higher order clustering.
引用
收藏
页码:213 / 219
页数:7
相关论文
共 56 条
[1]   Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme [J].
Aritomi, M ;
Kunishima, N ;
Okamoto, T ;
Kuroki, R ;
Ota, Y ;
Morikawa, K .
NATURE, 1999, 401 (6754) :713-718
[2]   CRYSTAL-STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX - IMPLICATIONS FOR TNF RECEPTOR ACTIVATION [J].
BANNER, DW ;
DARCY, A ;
JANES, W ;
GENTZ, R ;
SCHOENFELD, HJ ;
BROGER, C ;
LOETSCHER, H ;
LESSLAUER, W .
CELL, 1993, 73 (03) :431-445
[3]  
Barclay AN, 1997, The Leucocyte antigen facts book
[4]   The structure of the two amino-terminal domains of human intercellular adhesion molecule-1 suggests how it functions as a rhinovirus receptor [J].
Bella, J ;
Kolatkar, PR ;
Marlor, CW ;
Greve, JM ;
Rossmann, MG .
VIRUS RESEARCH, 1999, 62 (02) :107-117
[5]   Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor [J].
Bennett, MJ ;
Lebrón, JA ;
Bjorkman, PJ .
NATURE, 2000, 403 (6765) :46-53
[6]   Structure of CD94 reveals a novel C-type lectin fold: Implications for the NK cell-associated CD94/NKG2 receptors [J].
Boyington, JC ;
Riaz, AN ;
Patamawenu, A ;
Coligan, JE ;
Brooks, AG ;
Sun, PD .
IMMUNITY, 1999, 10 (01) :75-82
[7]   2.8 Å resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity [J].
Cha, SS ;
Kim, MS ;
Choi, YH ;
Sung, BJ ;
Shin, NK ;
Shin, HC ;
Sung, YC ;
Oh, BH .
IMMUNITY, 1999, 11 (02) :253-261
[8]   Structure of adenovirus complexed with its internalization receptor, αvβ5 integrin [J].
Chiu, CY ;
Mathias, P ;
Nemerow, GR ;
Stewart, PL .
JOURNAL OF VIROLOGY, 1999, 73 (08) :6759-6768
[9]   An extensively modified version of MolScript that includes greatly enhanced coloring capabilities [J].
Esnouf, RM .
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 1997, 15 (02) :132-+
[10]   Structural basis of T cell recognition [J].
Garcia, KC ;
Teyton, L ;
Wilson, LA .
ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :369-+