RAS unplugged: Negative feedback and oncogene-induced senescence

被引:23
作者
Bardeesy, Nabeel [1 ]
Sharpless, Norman E.
机构
[1] Univ N Carolina, Dept Med, Sch Med, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Genet, Sch Med, Chapel Hill, NC 27599 USA
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med,Canc Ctr, Boston, MA 02114 USA
关键词
D O I
10.1016/j.ccr.2006.11.015
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Many normal cells respond to certain stresses, such as oncogene activation, by undergoing a permanent form of growth arrest known as senescence, an intrinsic tumor suppressor program. The predominant view has been that senescence is caused in some settings through a mutant oncogene's ability to induce activation of high levels of sustained MAP kinase and PI3 kinase signaling. A new study in this issue of Cancer Cell has challenged this model with the surprising finding that aberrant activation of the RAS/RAF pathway can induce a negative feedback loop that globally attenuates MAPK and PI3K signaling and that the reduction of signaling in these pathways is required for senescence.
引用
收藏
页码:451 / 453
页数:3
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