Interleukin-6 level in patients with colorectal cancer

Interleukin-6 (IL-6) contributes to a multitude of physiological and pathophysiological processes. We sought to determine the level of the IL-6 in serum and tumoral tissue of patients with staging of the tumor and whether serum IL-6 level in patients with colorectal cancer correlate with tumoral tissue level of it. Serum and tumoral tissue specimen (stored at - 80 degrees C until the biochemical determination) from colorectal cancer (n = 50) were examined for IL-6.we determined the IL-6 Level in serum and tumoral tissue supernatant with Instant ELISA kit. A significant association between serum IL-6 level and staging of the tumor (P < 0.001), tumoral tissue IL-6 level (r=0.95, P < 0.001) in the patients was founded. IL-6 amount of the serum and tumoral tissue in the patients with colorectal cancer correlate significantly with the staging of the tumor and with each other. (c) 2005 Published by Elsevier Ireland Ltd.