Vascular endothelial growth factor expression in osteosarcoma

被引:43
作者
Charity, R. M. [1 ]
Foukas, A. F. [1 ]
Deshmukh, N. S. [1 ]
Grimer, R. J. [1 ]
机构
[1] Royal Orthopaed Hosp, Dept Orthopaed Oncol, Birmingham B31 2AP, W Midlands, England
关键词
NEOADJUVANT CHEMOTHERAPY; PULMONARY METASTASIS; TUMOR ANGIOGENESIS; OSTEOGENIC-SARCOMA; POOR-PROGNOSIS; FACTOR VEGF; PROGRESSION; EXPERIENCE; EXTREMITY; ADJUVANT;
D O I
10.1097/01.blo.0000205877.05093.c9
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Vascular endothelial growth factor expression by osteosarcomas at biopsy has been shown to have a negative influence on survival. Whether it continues to be expressed and influence outcome in tumors after neoadjuvant chemotherapy has not been determined. To determine if a high-degree of vascular endothelial growth factor expression by the surviving osteosarcoma cells in the resected tumor has a negative influence on prognosis, we retrospectively reviewed 52 patients with Stage IIB osteosarcoma around the knee, 48 of whom received neoadjuvant chemotherapy. Vascular endothelial growth factor expression by the surviving tumor cells in the surgically resected specimens was determined by immunohistochemical staining. Followup was for a minimum of 92 months. The presence of vascular endothelial growth factor expression in greater than 25% of tumor cells was independently associated with a reduced overall and disease-free survival rate.
引用
收藏
页码:193 / 198
页数:6
相关论文
共 26 条
[1]  
BACCI G, 1993, CANCER-AM CANCER SOC, V71, P1224, DOI 10.1002/1097-0142(19930215)71:4<1224::AID-CNCR2820710409>3.0.CO
[2]  
2-M
[3]   Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity - Histologic response to preoperative chemotherapy correlates with histologic subtype of the tumor [J].
Bacci, G ;
Bertoni, F ;
Longhi, A ;
Ferrari, S ;
Forni, C ;
Biagini, R ;
Bacchini, P ;
Donati, D ;
Manfrini, M ;
Bernini, G ;
Lari, S .
CANCER, 2003, 97 (12) :3068-3075
[4]   Osteosarcoma of the limb - Amputation or limb salvage in patients treated by neoadjuvant chemotherapy [J].
Bacci, G ;
Ferrari, S ;
Lari, S ;
Mercuri, M ;
Donati, D ;
Longhi, A ;
Forni, C ;
Bertoni, R ;
Versari, M ;
Pignotti, E .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2002, 84B :88-92
[5]   PROGNOSTIC FACTORS IN OSTEOSARCOMA - A CRITICAL-REVIEW [J].
DAVIS, AM ;
BELL, RS ;
GOODWIN, PJ .
JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (02) :423-431
[6]  
FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182
[7]   Stage-IIB osteosarcomas around the knee - A study of MMP-9 in surviving tumour cells [J].
Foukas, AF ;
Deshmukh, NS ;
Grimer, RJ ;
Mangham, DC ;
Mangos, EG ;
Taylor, S .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2002, 84B (05) :706-711
[8]  
Giavazzi R, 2001, CANCER RES, V61, P309
[9]  
GLASSER DB, 1992, CANCER, V69, P698, DOI 10.1002/1097-0142(19920201)69:3<698::AID-CNCR2820690317>3.0.CO
[10]  
2-G