Early aggressive treatment for Merkel cell carcinoma improves outcome

被引:147
作者
Kokoska, ER
Kokoska, MS
Collins, BT
Stapleton, DR
Wade, TP
机构
[1] ST LOUIS UNIV,HLTH SCI CTR,DEPT SURG,ST LOUIS,MO 63110
[2] ST LOUIS UNIV,HLTH SCI CTR,DEPT OTOLARYNGOL,ST LOUIS,MO 63110
[3] ST LOUIS UNIV,HLTH SCI CTR,DEPT PATHOL,ST LOUIS,MO 63110
[4] USAF,MED CTR,CANC COMM & TUMOR REGISTRY,SCOTT AFB,IL
关键词
D O I
10.1016/S0002-9610(97)00193-1
中图分类号
R61 [外科手术学];
学科分类号
摘要
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of dermal origin, Treatment recommendations are limited owing to a paucity of retrospective data and an absence of prospective data. The objective of this study was to determine current therapeutic trends and their impact upon outcome, METHODS: A retrospective study (1983 to 1996) was performed with patients from the Department of Defense and our University-affiliate hospitals, RESULTS: Thirty-five patients were evaluated with a mean follow-up of 31 months, Overall, 1- and 2-year survival rates were 80% and 50%, respectively, Patients undergoing wide local excision, prophylactic lymph node dissection, and adjuvant radiotherapy had significantly decreased locoregional and distant recurrence rates and improved survival when compared with their counterparts, Adjuvant chemotherapy did not diminish recurrence rates nor improve survival. Both locoregional and distant recurrence significantly decreased survival, CONCLUSIONS: These data suggest that early aggressive treatment for MCC improves both tumor control and survival, whereas the early use of chemotherapy does not improve outcome, (C) 1997 by Excerpta Medica, Inc.
引用
收藏
页码:688 / 693
页数:6
相关论文
共 30 条
[1]  
COTLAR AM, 1986, AM SURGEON, V52, P159
[2]  
FEUN LG, 1988, CANCER, V62, P683, DOI 10.1002/1097-0142(19880815)62:4<683::AID-CNCR2820620406>3.0.CO
[3]  
2-J
[4]   MILITARYS ROLE IN THE WAR AGAINST CANCER - AN EXPANDING HORIZON [J].
GHOSH, BC ;
JAKLIC, B .
JOURNAL OF SURGICAL ONCOLOGY, 1994, 56 (03) :145-145
[5]  
GOEPFERT H, 1984, ARCH OTOLARYNGOL, V110, P707
[6]  
GOMEZ LG, 1981, LAB INVEST, V44, P24
[7]   NEURO-ENDOCRINE (MERKEL CELL) CARCINOMA OF THE SKIN - ITS NATURAL-HISTORY, DIAGNOSIS, AND TREATMENT [J].
HITCHCOCK, CL ;
BLAND, KI ;
LANEY, RG ;
FRANZINI, D ;
HARRIS, B ;
COPELAND, EM .
ANNALS OF SURGERY, 1988, 207 (02) :201-207
[8]  
JOHANNESSEN JV, 1980, HUM PATHOL, V11, P586
[9]  
KROLL MH, 1982, ARCH PATHOL LAB MED, V106, P404
[10]  
MARKS ME, 1990, CANCER, V65, P60, DOI 10.1002/1097-0142(19900101)65:1<60::AID-CNCR2820650113>3.0.CO