The enigma of Huntington's disease

被引：11

作者：

Cattaneo, E ^{[1
]}

Rigamonti, D

Zuccato, C

机构：

[1] Univ Milan, Dept Pharmacol Sci, I-20122 Milan, Italy

[2] Univ Milan, Ctr Excellence Neurodegenerat Dis, I-20122 Milan, Italy

[3] Univ Insubria, Varese, Italy

来源：

SCIENTIFIC AMERICAN | 2002年 / 287卷 / 06期

关键词：

D O I：

10.1038/scientificamerican1202-92

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A description of huntingtons disease and the gene which is responsible for it is presented. Huntingtons disease, which cripples and causes dementia is a genetic disease that results from a mutation in a gene called huntingtin found on chromosome 4. Mutant hutingtin appears to be toxic to key nerve cells in the brain and lacks the ability to turn on a necessary growth factor gene.

引用

页码：92 / 97

页数：6

共 3 条

[1] Loss of normal huntingtin function: new developments in Huntington's disease research [J].

Cattaneo, E ;

Rigamonti, D ;

Goffredo, D ;

Zuccato, C ;

Squitieri, F ;

Sipione, S .

TRENDS IN NEUROSCIENCES, 2001, 24 (03) :182-188

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CELL, 1993, 72 (06) :971-983

[3] Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease [J].

Zuccato, C ;

Ciammola, A ;

Rigamonti, D ;

Leavitt, BR ;

Goffredo, D ;

Conti, L ;

MacDonald, ME ;

Friedlander, RM ;

Silani, V ;

Hayden, MR ;

Timmusk, T ;

Sipione, S ;

Cattaneo, E .

SCIENCE, 2001, 293 (5529) :493-498

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