Variant in PNPLA3 is associated with alcoholic liver disease

被引：344

作者：

Tian, Chao ^{[1
]}

Stokowski, Renee P. ^{[1
]}

Kershenobich, David ^{[2
]}

Ballinger, Dennis G. ^{[1
,3
]}

Hinds, David A. ^{[1
]}

机构：

[1] Perlegen Sci, Mountain View, CA USA

[2] Univ Nacl Autonoma Mexico, Fac Med, Dept Expt Med, Mexico City 04510, DF, Mexico

[3] Complete Genom, Mountain View, CA USA

来源：

NATURE GENETICS | 2010年 / 42卷 / 01期

关键词：

ADIPONUTRIN; AMERICANS; CIRRHOSIS; RISK;

D O I：

10.1038/ng.488

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR = 2.25, P = 1.7 x 10(-10); ancestry-adjusted OR = 1.79, P = 1.9 x 10(-5)).

引用

页码：21 / 23

页数：3

共 15 条

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