Murine macrophages stimulated with central and peripheral nervous system myelin or purified myelin proteins release inflammatory products

被引：31

作者：

Constantinescu, CS

Goodman, DB

Hilliard, B

Wysocka, M

Cohen, JA

机构：

[1] Univ Leicester, Dept Microbiol & Immunol, Leicester LE1 9HN, Leics, England

[2] Univ Penn, Philadelphia, PA 19104 USA

[3] Wistar Inst, Philadelphia, PA 19104 USA

[4] Cleveland Clin Fdn, Mellen Ctr Multiple Sclerosis Treatment & Res, Cleveland, OH 44195 USA

来源：

NEUROSCIENCE LETTERS | 2000年 / 287卷 / 03期

关键词：

angiotensin converting enzyme; demyelination; interleukin-12; macrophages; myelin; opsonization; tumor necrosis factor;

D O I：

10.1016/S0304-3940(00)01184-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Macrophage inflammatory products including tumor necrosis factor (TNF) and interleukin-12/p40 are implicated in demyelinating diseases such as multiple sclerosis (MS), Guillain-Barre syndrome, and animal models experimental autoimmune encephalomyelitis and neuritis. The macrophage product angiotensin converting enzyme (ACE) is released during inflammation. ACE can also be elevated in MS. We investigated the ability of central (CNS) and peripheral nervous system (PNS) myelin to stimulate TNF, interleukin-12, and ACE production by murine macrophages. Both CNS and PNS myelin and purified myelin basic protein and P2 protein induced release of these products. Direct stimulation by myelin may represent a mechanism of inducing release of macrophage products in inflammatory demyelination or neural injury. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：171 / 174

页数：4

共 21 条

[1] PRODUCTION OF TUMOR-NECROSIS-FACTOR AND OTHER PROINFLAMMATORY CYTOKINES BY HUMAN MONONUCLEAR PHAGOCYTES STIMULATED WITH MYELIN P2-PROTEIN [J].