The distribution of cerebrovascular amyloid in Alzheimer's disease varies with ApoE genotype

被引:33
作者
Trembath, Dimitri
Ervin, John F.
Broom, Lucy
Szymanski, Mari
Welsh-Bohmer, Kathleen
Pieper, Carl
Hulette, Christine M.
机构
[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21218 USA
[3] Duke Univ, Med Ctr, Dept Med Neurol, Durham, NC 27710 USA
[4] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA
[5] Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Durham, NC 27710 USA
基金
美国国家卫生研究院;
关键词
Alzheimer's disease (AD); cerebral amyloid angiopathy (CAA); ApoE; amyloid beta (A beta); cerebral arterioles;
D O I
10.1007/s00401-006-0162-9
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We performed a comparative study to assess cerebral amyloid angiopathy and ApoE genotype in cases of Alzheimer's disease (AD). Ten ApoE 3,3 and ten ApoE 4,4 AD brains, as well as ten normal control brains, were selected after matching for age, sex, and duration of disease. Sections of middle frontal and inferior parietal cortex including white matter sections were stained with an antibody against amyloid beta (A beta), and extensive analysis of arteriolar AP deposition was performed using digital image analysis. Quantification of the staining revealed a larger cross-section of arteriolar walls occupied by AP in ApoE 4,4 and ApoE 3,3 AD subjects compared to controls. Our results show A beta deposition in gray matter and white matter arterioles was predominantly found in ApoE 4,4 brains and, overall, A beta deposition was greatest in these cases. This observation implies that there is greater vascular amyloid deposition (particularly in the white matter arterioles) in ApoE 4,4 AD individuals compared to ApoE 3,3 AD. These observations may give insight into the etiology behind the increased risk for AD associated with the ApoE-epsilon 4 allele and the pathogenesis of vascular A beta deposition.
引用
收藏
页码:23 / 31
页数:9
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