Non-synaptic dendritic spines in neocortex

被引：125

作者：

Arellano, J. I.

Espinosa, A.

Fairen, A.

Yuste, R.

DeFelipe, J.

机构：

[1] CSIC, Inst Cajal, Dept Neuroanat & Biol Celular, Madrid 280002, Spain

[2] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06520 USA

[3] CISC, Inst Neurociencias Alicante, Alacant 03550, Spain

[4] Univ Miguel Hernandez, Alacant 03550, Spain

[5] Columbia Univ, Dept Biol Sci, Howard Hughes Med Inst, New York, NY 10027 USA

来源：

NEUROSCIENCE | 2007年 / 145卷 / 02期

关键词：

pyramidal neurons; excitatory synapses; serial section reconstructions;

D O I：

10.1016/j.neuroscience.2006.12.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Along-held assumption states that each dendritic spine in the cerebral cortex forms a synapse, although this issue has not been systematically investigated. We performed complete ultrastructural reconstructions of a large (n=144) population of identified spines in adult mouse neocortex finding that only 3.6% of the spines clearly lacked synapses. Nonsynaptic spines were small and had no clear head, resembling dendritic filopodia, and could represent a source of new synaptic connections in the adult cerebral cortex. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：464 / 469

页数：6

共 31 条

[1] Density and morphology of dendritic spines in mouse neocortex [J].