One-pot Mitsunobu-Staudinger preparation of 3-aminocholan-24-oic acid esters from 3-hydroxycholan-24-oic acid esters

被引：42

作者：

Anelli, PL ^{[1
]}

Lattuada, L ^{[1
]}

Uggeri, F ^{[1
]}

机构：

[1] Bracco Ind Chim Spa, Milano Res Ctr, I-20134 Milan, Italy

来源：

SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 01期

关键词：

D O I：

10.1080/00397919808005079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Hydroxycholan-24-oic acid esters are easily converted into the corresponding 3-amino derivatives via Mitsunobu reaction with diphenylphosphoryl azide (DPPA) and Staudinger reduction with PPh3/H2O of the intermediate azido compound in THF.

引用

页码：109 / 117

页数：9

共 23 条

[1] Anelli PL, 1996, GAZZ CHIM ITAL, V126, P89
[2] ANELLI PL, 1994, Patent No. 32741
[3] ANELLI PL, 1994, Patent No. 07426
[4] BELLINI AM, 1986, FARMACO, V41, P401
[5] NEW PROCEDURES FOR SELECTIVELY PROTECTED CHOLIC-ACID DERIVATIVES - REGIOSELECTIVE PROTECTION OF THE 12-ALPHA-OH GROUP, AND TERT-BUTYL ESTERIFICATION OF THE CARBOXYL GROUP
BONARLAW, RP
DAVIS, AP
SANDERS, JKM
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (08): : 2245 - 2250
[6] BOSE AK, 1973, TETRAHEDRON LETT, P1619
[7] POTENTIAL BILE-ACID METABOLITES .2. 3,7,12-TRISUBSTITUTED 5 BETA-CHOLANIC ACIDS
CHANG, FC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (25) : 4567 - 4572
[8] CHOLAPHANES ET-AL - STEROIDS AS STRUCTURAL COMPONENTS IN MOLECULAR ENGINEERING
DAVIS, AP
[J]. CHEMICAL SOCIETY REVIEWS, 1993, 22 (04) : 243 - 253
[9] PARA-TOLUENE SULFONIC-ACID METHANOL - MILD REAGENT FOR THE PREPARATION OF BILE-ACID METHYL-ESTERS
DAYAL, B
SPECK, J
BAGAN, E
TINT, GS
SALEN, G
[J]. STEROIDS, 1981, 37 (02) : 239 - 242
[10] Gries H, 1981, Patent DE-OS, Patent No. [3129906 A1, 3129906]

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