Group II introns: structure, folding and splicing mechanism

被引：85

作者：

Fedorova, Olga ^{[1
]}

Zingler, Nora

机构：

[1] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

BIOLOGICAL CHEMISTRY | 2007年 / 388卷 / 07期

关键词：

catalytic RNA; protein-assisted splicing; ribozyme;

D O I：

10.1515/BC.2007.090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Group II introns are large autocatalytic RNAs found in organellar genomes of plants and lower eukaryotes, as well as in some bacterial genomes. Interestingly, these ribozymes share characteristic traits with both spliceosomal introns and non-LTR retrotransposons and may have a common evolutionary ancestor. Furthermore, group II intron features such as structure, folding and catalytic mechanism differ considerably from those of other large ribozymes, making group II introns an attractive model system to gain novel insights into RNA biology and biochemistry. This review explores recent advances in the structural and mechanistic characterization of group II intron architecture and self-splicing.

引用

页码：665 / 678

页数：14

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