Codon reassignment and amino acid composition in hemichordate mitochondria

被引:71
作者
Castresana, J [1 ]
Feldmaier-Fuchs, G [1 ]
Pääbo, S [1 ]
机构
[1] Univ Munich, Inst Zool, D-80333 Munich, Germany
关键词
Balanoglossus carnosus; codon capture; genetic code change; neutral theory; protein evolution;
D O I
10.1073/pnas.95.7.3703
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In the mitochondrial genome of the hemichordate Balanoglossus carnosus, the codon AAA, which is assigned to lysine in most metazoans but to asparagine in echinoderms, is absent, Furthermore, the lysine tRNA gene carries an anticodon substitution that renders its gene product unable to decode AAA codons, whereas the asparagine tRNA gene has not changed to encode a tRNA with the ability to recognize AAA codons, Thus, the hemichordate mitochondrial genome can be regarded as an intermediate in the process of reassignment of mitochondrial AAA codons, where most metazoans represent the ancestral situation and the echinoderms the derived situation, This lends support to the codon capture hypothesis, We also show that the reassignment of the AAA codon is associated with a reduction in the relative abundance of lysine residues in mitochondrial proteins.
引用
收藏
页码:3703 / 3707
页数:5
相关论文
共 36 条
[1]   SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME [J].
ANDERSON, S ;
BANKIER, AT ;
BARRELL, BG ;
DEBRUIJN, MHL ;
COULSON, AR ;
DROUIN, J ;
EPERON, IC ;
NIERLICH, DP ;
ROE, BA ;
SANGER, F ;
SCHREIER, PH ;
SMITH, AJH ;
STADEN, R ;
YOUNG, IG .
NATURE, 1981, 290 (5806) :457-465
[2]  
ANDERSSON SGE, 1991, MOL BIOL EVOL, V8, P530
[3]  
ASAKAWA S, 1995, GENETICS, V140, P1047
[4]  
BARRELL BG, 1979, NATURE, V282, P189, DOI 10.1038/282189a0
[5]   GenBank [J].
Benson, DA ;
Boguski, MS ;
Lipman, DJ ;
Ostell, J ;
Ouellette, BFF .
NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :1-7
[6]   PLANARIAN MITOCHONDRIA .2. THE UNIQUE GENETIC-CODE AS DEDUCED FROM CYTOCHROME-C-OXIDASE SUBUNIT-I GENE-SEQUENCES [J].
BESSHO, Y ;
OHAMA, T ;
OSAWA, S .
JOURNAL OF MOLECULAR EVOLUTION, 1992, 34 (04) :331-335
[7]  
BOORE JL, 1995, GENETICS, V141, P305
[8]   THE MITOCHONDRIAL-DNA MOLECULE OF DROSOPHILA-YAKUBA - NUCLEOTIDE-SEQUENCE, GENE ORGANIZATION, AND GENETIC-CODE [J].
CLARY, DO ;
WOLSTENHOLME, DR .
JOURNAL OF MOLECULAR EVOLUTION, 1985, 22 (03) :252-271
[9]   DROSOPHILA-MELANOGASTER MITOCHONDRIAL-DNA, A NOVEL ORGANIZATION AND GENETIC-CODE [J].
DEBRUIJN, MHL .
NATURE, 1983, 304 (5923) :234-241
[10]   PLATYHELMINTH MITOCHONDRIAL-DNA - EVIDENCE FOR EARLY EVOLUTIONARY ORIGIN OF A TRANSFER RNASERAGN THAT CONTAINS A DIHYDROURIDINE ARM REPLACEMENT LOOP, AND OF SERINE-SPECIFYING AGA AND AGG CODONS [J].
GAREY, JR ;
WOLSTENHOLME, DR .
JOURNAL OF MOLECULAR EVOLUTION, 1989, 28 (05) :374-387