Erythropoietin in amniotic fluid as a marker of chronic fetal hypoxia

被引：29

作者：

Buescher, U ^{[1
]}

Hertwig, K ^{[1
]}

Wolf, C ^{[1
]}

Dudenhausen, JW ^{[1
]}

机构：

[1] Free Univ Berlin, Rudolf Virchow Hosp, Dept Obstet, D-1000 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 1998年 / 60卷 / 03期

关键词：

erythropoietin; amniotic fluid; pregnancy; fetal hypoxia; preeclampsia; diabetes mellitus;

D O I：

10.1016/S0020-7292(98)00011-3

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determinate the erythropoietin concentration in amniotic fluid in normal pregnancies and pregnancies with suspected hypoxia. Method: The erythropoietin concentration of 164 samples of amniotic fluid was determined by ELISA. The samples were taken by amniotomy during birth, as well as amniocentesis conducted during prenatal care. Results: A distribution of 1.07-7.29 U/1 (10th-90th percentile) within the normal group (n = 106) was determined. Significantly elevated erythropoietin levels in amniotic fluid were determined in maternal hypertension (P = 0.039) and low birth-weight children (P = 0.0032). A correlation with the child's sex could be excluded. Conclusion: Elevated erythropoietin levels in amniotic fluid indicated chronic fetal hypoxia. (C) 1998 International Federation of Gynecology and Obstetrics.

引用

页码：257 / 263

页数：7

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