共 65 条
Leptin system in embryo development and implantation:: a protein in search of a function
被引:62
作者:

Cervero, A
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机构: Fdn IVI, Valencia 46015, Spain

Horcajadas, JA
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h-index: 0
机构: Fdn IVI, Valencia 46015, Spain

Domínguez, F
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h-index: 0
机构: Fdn IVI, Valencia 46015, Spain

Pellicer, A
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h-index: 0
机构: Fdn IVI, Valencia 46015, Spain

Simón, C
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h-index: 0
机构: Fdn IVI, Valencia 46015, Spain
机构:
[1] Fdn IVI, Valencia 46015, Spain
[2] Univ Valencia, Sch Med, Dept Pediat Obstet & Gynecol, E-46003 Valencia, Spain
关键词:
embryo;
implantation;
leptin;
leptin receptor;
D O I:
10.1016/S1472-6483(10)60943-1
中图分类号:
R71 [妇产科学];
学科分类号:
100211 ;
摘要:
Implantation is a crucial moment in the reproduction process that requires perfect synchronization between the embryo and the maternal endometrium. The embryo must reach the blastocyst stage and the endometrium must be prepared to receive it. An appropriate and specific molecular dialogue must also take place between them. There is ample evidence to show that the leptin system is implicated in this cross-talk. Examples are described. Although there is some controversy surrounding the data, they are supported by the presence of leptin receptor mRNA in mouse and human oocytes and embryos throughout preimplantation development. Otherwise, the leptin mRNA is only detected at the blastocyst stage in both human and mouse. Furthermore, leptin is found at higher concentrations in the conditioned media from competent human blastocysts than in those from arrested embryos, suggesting that this molecule is a marker for blastocyst viability. Given that expression of the leptin receptor increases in the human endometrium during the luteal phase, the secreted leptin could trigger its activation. Finally, leptin and the leptin receptor have been detected in implantation sites. All these findings point to the involvement of the leptin system in the molecular mechanism of the implantation process and embryo development.
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页码:217 / 223
页数:7
相关论文
共 65 条
[1]
Role of leptin in the neuroendocrine response to fasting
[J].
Ahima, RS
;
Prabakaran, D
;
Mantzoros, C
;
Qu, DQ
;
Lowell, B
;
MaratosFlier, E
;
Flier, JS
.
NATURE,
1996, 382 (6588)
:250-252

Ahima, RS
论文数: 0 引用数: 0
h-index: 0
机构: BETH ISRAEL HOSP,DEPT MED,DIV ENDOCRINOL,BOSTON,MA 02215

Prabakaran, D
论文数: 0 引用数: 0
h-index: 0
机构: BETH ISRAEL HOSP,DEPT MED,DIV ENDOCRINOL,BOSTON,MA 02215

Mantzoros, C
论文数: 0 引用数: 0
h-index: 0
机构: BETH ISRAEL HOSP,DEPT MED,DIV ENDOCRINOL,BOSTON,MA 02215

Qu, DQ
论文数: 0 引用数: 0
h-index: 0
机构: BETH ISRAEL HOSP,DEPT MED,DIV ENDOCRINOL,BOSTON,MA 02215

Lowell, B
论文数: 0 引用数: 0
h-index: 0
机构: BETH ISRAEL HOSP,DEPT MED,DIV ENDOCRINOL,BOSTON,MA 02215

MaratosFlier, E
论文数: 0 引用数: 0
h-index: 0
机构: BETH ISRAEL HOSP,DEPT MED,DIV ENDOCRINOL,BOSTON,MA 02215

Flier, JS
论文数: 0 引用数: 0
h-index: 0
机构: BETH ISRAEL HOSP,DEPT MED,DIV ENDOCRINOL,BOSTON,MA 02215
[2]
The endometrium as a novel target for leptin: differences in fertility and subfertility
[J].
Alfer, J
;
Muller-Schottle, F
;
Classen-Linke, I
;
von Rango, U
;
Happel, L
;
Beier-Hellwig, K
;
Rath, W
;
Beier, HM
.
MOLECULAR HUMAN REPRODUCTION,
2000, 6 (07)
:595-601

Alfer, J
论文数: 0 引用数: 0
h-index: 0
机构: Rhein Westfal TH Univ Aachen, Dept Anat & Reprod Biol, D-52057 Aachen, Germany

Muller-Schottle, F
论文数: 0 引用数: 0
h-index: 0
机构: Rhein Westfal TH Univ Aachen, Dept Anat & Reprod Biol, D-52057 Aachen, Germany

Classen-Linke, I
论文数: 0 引用数: 0
h-index: 0
机构: Rhein Westfal TH Univ Aachen, Dept Anat & Reprod Biol, D-52057 Aachen, Germany

von Rango, U
论文数: 0 引用数: 0
h-index: 0
机构: Rhein Westfal TH Univ Aachen, Dept Anat & Reprod Biol, D-52057 Aachen, Germany

Happel, L
论文数: 0 引用数: 0
h-index: 0
机构: Rhein Westfal TH Univ Aachen, Dept Anat & Reprod Biol, D-52057 Aachen, Germany

Beier-Hellwig, K
论文数: 0 引用数: 0
h-index: 0
机构: Rhein Westfal TH Univ Aachen, Dept Anat & Reprod Biol, D-52057 Aachen, Germany

Rath, W
论文数: 0 引用数: 0
h-index: 0
机构: Rhein Westfal TH Univ Aachen, Dept Anat & Reprod Biol, D-52057 Aachen, Germany

Beier, HM
论文数: 0 引用数: 0
h-index: 0
机构: Rhein Westfal TH Univ Aachen, Dept Anat & Reprod Biol, D-52057 Aachen, Germany
[3]
Normal reproductive function in leptin-deficient patients with lipoatropic diabetes
[J].
Andreelli, F
;
Hanaire-Broutin, H
;
Laville, M
;
Tauber, JP
;
Riou, JP
;
Thivolet, C
.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,
2000, 85 (02)
:715-719

Andreelli, F
论文数: 0 引用数: 0
h-index: 0
机构: Hop Edouard Herriot, Dept Endocrinol & Diabet, F-69437 Lyon 03, France

Hanaire-Broutin, H
论文数: 0 引用数: 0
h-index: 0
机构: Hop Edouard Herriot, Dept Endocrinol & Diabet, F-69437 Lyon 03, France

Laville, M
论文数: 0 引用数: 0
h-index: 0
机构: Hop Edouard Herriot, Dept Endocrinol & Diabet, F-69437 Lyon 03, France

Tauber, JP
论文数: 0 引用数: 0
h-index: 0
机构: Hop Edouard Herriot, Dept Endocrinol & Diabet, F-69437 Lyon 03, France

Riou, JP
论文数: 0 引用数: 0
h-index: 0
机构: Hop Edouard Herriot, Dept Endocrinol & Diabet, F-69437 Lyon 03, France

Thivolet, C
论文数: 0 引用数: 0
h-index: 0
机构: Hop Edouard Herriot, Dept Endocrinol & Diabet, F-69437 Lyon 03, France
[4]
Oocyte influences on early development: the regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cells of the preimplantation stage embryo
[J].
Antczak, M
;
Van Blerkom, J
.
MOLECULAR HUMAN REPRODUCTION,
1997, 3 (12)
:1067-1086

Antczak, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

Van Blerkom, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
[5]
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
[J].
Bates, SH
;
Stearns, WH
;
Dundon, TA
;
Schubert, M
;
Tso, AWK
;
Wang, YP
;
Banks, AS
;
Lavery, HJ
;
Haq, AK
;
Maratos-Flier, E
;
Neel, BG
;
Schwartz, MW
;
Myers, MG
.
NATURE,
2003, 421 (6925)
:856-859

Bates, SH
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Stearns, WH
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Dundon, TA
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Schubert, M
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Tso, AWK
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Wang, YP
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Banks, AS
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Lavery, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Haq, AK
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Maratos-Flier, E
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Neel, BG
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Schwartz, MW
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Myers, MG
论文数: 0 引用数: 0
h-index: 0
机构: Beth Israel Deaconess Med Ctr, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA
[6]
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
[J].
Baumann, H
;
Morella, KK
;
White, DW
;
Dembski, M
;
Bailon, PS
;
Kim, HK
;
Lai, CF
;
Tartaglia, LA
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1996, 93 (16)
:8374-8378

Baumann, H
论文数: 0 引用数: 0
h-index: 0
机构: MILLENNIUM PHARMACEUT INC,CAMBRIDGE,MA 02139

Morella, KK
论文数: 0 引用数: 0
h-index: 0
机构: MILLENNIUM PHARMACEUT INC,CAMBRIDGE,MA 02139

White, DW
论文数: 0 引用数: 0
h-index: 0
机构: MILLENNIUM PHARMACEUT INC,CAMBRIDGE,MA 02139

Dembski, M
论文数: 0 引用数: 0
h-index: 0
机构: MILLENNIUM PHARMACEUT INC,CAMBRIDGE,MA 02139

Bailon, PS
论文数: 0 引用数: 0
h-index: 0
机构: MILLENNIUM PHARMACEUT INC,CAMBRIDGE,MA 02139

Kim, HK
论文数: 0 引用数: 0
h-index: 0
机构: MILLENNIUM PHARMACEUT INC,CAMBRIDGE,MA 02139

Lai, CF
论文数: 0 引用数: 0
h-index: 0
机构: MILLENNIUM PHARMACEUT INC,CAMBRIDGE,MA 02139

Tartaglia, LA
论文数: 0 引用数: 0
h-index: 0
机构: MILLENNIUM PHARMACEUT INC,CAMBRIDGE,MA 02139
[7]
Divergent signaling capacities of the long and short isoforms of the leptin receptor
[J].
Bjorbaek, C
;
Uotani, S
;
da Silva, B
;
Flier, JS
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1997, 272 (51)
:32686-32695

Bjorbaek, C
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol,Dept Med, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol,Dept Med, Boston, MA 02215 USA

Uotani, S
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol,Dept Med, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol,Dept Med, Boston, MA 02215 USA

da Silva, B
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol,Dept Med, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol,Dept Med, Boston, MA 02215 USA

Flier, JS
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol,Dept Med, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol,Dept Med, Boston, MA 02215 USA
[8]
Serum and follicular fluid leptin during in vitro fertilization:: Relationship among leptin increase, body fat mass, and reduced ovarian response
[J].
Bützow, TL
;
Moilanen, JM
;
Lehtovirta, M
;
Tuomi, T
;
Hovatta, O
;
Siegberg, R
;
Nilsson, CG
;
Apter, D
.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,
1999, 84 (09)
:3135-3139

Bützow, TL
论文数: 0 引用数: 0
h-index: 0
机构: Family Federat Finland, FIN-00100 Helsinki, Finland

Moilanen, JM
论文数: 0 引用数: 0
h-index: 0
机构: Family Federat Finland, FIN-00100 Helsinki, Finland

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Siegberg, R
论文数: 0 引用数: 0
h-index: 0
机构: Family Federat Finland, FIN-00100 Helsinki, Finland

Nilsson, CG
论文数: 0 引用数: 0
h-index: 0
机构: Family Federat Finland, FIN-00100 Helsinki, Finland

Apter, D
论文数: 0 引用数: 0
h-index: 0
机构: Family Federat Finland, FIN-00100 Helsinki, Finland
[9]
The OB protein (leptin) pathway - A link between adipose tissue mass and central neural networks
[J].
Campfield, LA
;
Smith, FJ
;
Burn, P
.
HORMONE AND METABOLIC RESEARCH,
1996, 28 (12)
:619-632

Campfield, LA
论文数: 0 引用数: 0
h-index: 0
机构: Department of Metabolic Diseases, Hoffmann-La Roche Inc., Nutley, NJ

Smith, FJ
论文数: 0 引用数: 0
h-index: 0
机构: Department of Metabolic Diseases, Hoffmann-La Roche Inc., Nutley, NJ

Burn, P
论文数: 0 引用数: 0
h-index: 0
机构: Department of Metabolic Diseases, Hoffmann-La Roche Inc., Nutley, NJ
[10]
Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF
[J].
Cao, RH
;
Brakenhielm, E
;
Wahlestedt, C
;
Thyberg, J
;
Cao, YH
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2001, 98 (11)
:6390-6395

Cao, RH
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Inst, Lab Angiogenesis Res, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

Brakenhielm, E
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Inst, Lab Angiogenesis Res, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

Wahlestedt, C
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Inst, Lab Angiogenesis Res, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

Thyberg, J
论文数: 0 引用数: 0
h-index: 0
机构: Karolinska Inst, Lab Angiogenesis Res, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

Cao, YH
论文数: 0 引用数: 0
h-index: 0
机构:
Karolinska Inst, Lab Angiogenesis Res, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden Karolinska Inst, Lab Angiogenesis Res, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden