Leukocyte angiotensin II levels in patients with essential hypertension: Relation to insulin resistance

被引：8

作者：

Fukuda, N ^{[1
]}

Nakayama, M ^{[1
]}

Jian, T ^{[1
]}

Satoh, C ^{[1
]}

Nakayama, T ^{[1
]}

Soma, M ^{[1
]}

Izumi, Y ^{[1
]}

Kanmatsuse, K ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Internal Med 2, Itabashi Ku, Tokyo 1738610, Japan

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2003年 / 16卷 / 02期

关键词：

hypertension; insulin resistance; leukocyte; angiotensin II; humans;

D O I：

10.1016/S0895-7061(02)03145-X

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Insulin resistance is involved in the pathogenesis of type 2 diabetes, hypertension, and atherosclerosis. Angiotensin (Ang) converting enzyme inhibitors and Ang II type 1 receptor antagonists improve insulin resistance in patients with essential hypertension, which suggest that tissue Ang II is involved in insulin resistance in patients with hypertension. To investigate the participation of tissue Ang II in insulin resistance associated with hypertension, we evaluated the Ang II-generating system in leukocytes and its relation to insulin resistance in patients with essential hypertension. Eighteen patients with essential hypertension participated in this study. Ang II was separated from leukocytes by reversed-phase high-performance liquid chromatography and measured by radioimmunoassay. Insulin resistance was evaluated by determining the steady-state of plasma glucose (SSPG) concentration. The Ang land Ang II-generating activities were evaluated in human leukocytes. Human leukocytes have Ang I- and Ang II-generating activities. The Ang II-generating activity was significantly inhibited by pepstatin A. Leukocyte Ang II level does not correlate with BP or plasma Ang II level in patients with essential hypertension. Leukocyte Ang II level strongly correlates with SSPG concentration, and significantly correlates with body mass index and plasma insulin, and with leptin levels in patients with essential hypertension. Leukocyte Ang I may be directly associated with insulin resistance. (C) 2003 American Journal of Hypertension, Ltd.

引用

页码：129 / 134

页数：6

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