Highly efficient diastereoselective Michael addition of various thiols to (+)-brefeldin A

被引：22

作者：

Argade, AB

Haugwitz, RD

Devraj, R

Kozlowski, J

Fanwick, PE

Cushman, M ^{[1
]}

机构：

[1] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

[2] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[3] NCI, Dev Therapeut Program, Div Canc Biol Diag & Ctr, NIH, Rockville, MD 20852 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 02期

关键词：

D O I：

10.1021/jo971292y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Michael addition of thiols to brefeldin A occurs with high diastereoselectivity, affording ratios of major to minor diastereomers of at least 30:1. On the basis of the X-ray structure of a crystalline dibenzoyl derivative, the major diastereomers are assigned the 3R configuration, while the minor diastereomers have the 3S configuration.

引用

页码：273 / 278

页数：6

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