Comprehensive geriatric assessment for older patients with cancer

被引:649
作者
Extermann, Martine
Hurria, Arti
机构
[1] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33612 USA
[2] City Hope Natl Med Ctr, Duarte, CA USA
关键词
D O I
10.1200/JCO.2007.10.6559
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose During the last decade, oncologists and geriatricians have begun to work together to integrate the principles of geriatrics into oncology care. The increasing use of a comprehensive geriatric assessment (CGA) is one example of this effort. A CGA includes an evaluation of an older individual's functional status, comorbid medical conditions, cognition, nutritional status, psychological state, and social support; and a review of the patient's medications. This article discusses recent advances on the use of a CGA in older patients with cancer. Methods In this article, we provide an update on the studies that address the domains of a geriatric assessment applied to the oncology patient, review the results of the first studies evaluating the use of a CGA in developing interventions to improve the care of older adults with cancer, and discuss future research directions. Results The evidence from recent studies demonstrates that a CGA can predict morbidity and mortality in older patients with cancer. Accumulating data show the benefits of incorporating a CGA in the evaluation of older patients with cancer. Prospective trials evaluating the utility of a CGA to guide interventions to improve the quality of cancer care in older adults are justified. Conclusion Growing evidence demonstrates that the variables examined in a CGA can predict morbidity and mortality in older patients with cancer, and uncover problems relevant to cancer care that would otherwise go unrecognized.
引用
收藏
页码:1824 / 1831
页数:8
相关论文
共 80 条
[1]   Preoperative assessment of surgical risk in oncogeriatric patients [J].
Audisio, RA ;
Ramesh, H ;
Longo, WE ;
Zbar, AP ;
Pope, D .
ONCOLOGIST, 2005, 10 (04) :262-268
[2]  
Balducci Lodovico, 2007, Cancer Control, V14, P7
[3]   Prognostic factors in non-small cell lung cancer surgery [J].
Birim, Ö ;
Kappetein, AP ;
van Klaveren, R ;
Bogers, AMC .
EJSO, 2006, 32 (01) :12-23
[4]   Undertreatment strongly decreases prognosis of breast cancer in elderly women [J].
Bouchardy, C ;
Rapiti, E ;
Fioretta, G ;
Laissue, P ;
Neyroud-Caspar, I ;
Schäfer, P ;
Kurtz, J ;
Sappino, AP ;
Vlastos, G .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (19) :3580-3587
[5]  
Callen LJ, 2004, J CLIN ONCOL, V22, p749S
[6]   Can older cancer patients tolerate chemotherapy? A prospective pilot study [J].
Chen, HB ;
Cantor, A ;
Meyer, J ;
Corcoran, MB ;
Grendys, E ;
Cavanaugh, D ;
Camarata, A ;
Haley, W ;
Balducci, L ;
Extermann, M .
CANCER, 2003, 97 (04) :1107-1114
[7]  
Corcoran, 1997, Cancer Control, V4, P419
[8]   Lifestyle intervention development study to improve physical function in older adults with cancer: Outcomes from Project LEAD [J].
Demark-Wahnefried, Wendy ;
Clipp, Elizabeth C. ;
Morey, Miriam C. ;
Pieper, Carl F. ;
Sloane, Richard ;
Clutter Snyder, Denise ;
Cohen, Harvey J. .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (21) :3465-3473
[9]   PROGNOSTIC EFFECT OF WEIGHT-LOSS PRIOR TO CHEMOTHERAPY IN CANCER-PATIENTS [J].
DEWYS, WD ;
BEGG, C ;
LAVIN, PT ;
BAND, PR ;
BENNETT, JM ;
BERTINO, JR ;
COHEN, MH ;
DOUGLASS, HO ;
ENGSTROM, PF ;
EZDINLI, EZ ;
HORTON, J ;
JOHNSON, GJ ;
MOERTEL, CG ;
OKEN, MM ;
PERLIA, C ;
ROSENBAUM, C ;
SILVERSTEIN, MN ;
SKEEL, RT .
AMERICAN JOURNAL OF MEDICINE, 1980, 69 (04) :491-497
[10]  
Di Fiore F, 2006, WORLD J GASTROENTERO, V12, P4185