Up against the wall

被引：8

作者：

Torres, Christian ^{[1
]}

机构：

[1] Nat Med, San Diego, CA USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 06期

关键词：

INFECTIOUS-DISEASES SOCIETY; AMERICA;

D O I：

10.1038/nm0610-628

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The notoriously drug-resistant bug MRSA has made headlines for years, but a whole other class of bacteria may prove even more troublesome. These microbes, Gram-negative bacteria, are increasingly a threat—and yet not a single late-stage drug in development specifically targets them. Christian Torres follows one man's quest to get the antibacterial pipeline flowing once again.

引用

收藏

页码：628 / 631

页数：4

相关论文

共 5 条

[1] Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America [J].

Boucher, Helen W. ;

Talbot, George H. ;

Bradley, John S. ;

Edwards, John E., Jr. ;

Gilbert, David ;

Rice, Louis B. ;

Scheld, Michael ;

Spellberg, Brad ;

Bartlett, John .

CLINICAL INFECTIOUS DISEASES, 2009, 48 (01) :1-12

[2] Multidrug Resistance among Gram-Negative Pathogens That Caused Healthcare-Associated Infections Reported to the National Healthcare Safety Network, 2006-2008 [J].

Kallen, Alexander J. ;

Hidron, Alicia I. ;

Patel, Jean ;

Srinivasan, Arjun .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2010, 31 (05) :528-531

[3] Trends in antimicrobial drug development: Implications for the future [J].

Spellberg, B ;

Powers, JH ;

Brass, EP ;

Miller, LG ;

Edwards, JE .

CLINICAL INFECTIOUS DISEASES, 2004, 38 (09) :1279-1286

[4] The epidemic of antibiotic-resistant infections: A call to action for the medical community from the Infectious Diseases Society of America [J].

Spellberg, Brad ;

Guidos, Robert ;

Gilbert, David ;

Bradley, John ;

Boucher, Helen W. ;

Scheld, W. Michael ;

Bartlett, John G. ;

Edwards, John, Jr. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (02) :155-164

[5] International Study of the Prevalence and Outcomes of Infection in Intensive Care Units [J].

Vincent, Jean-Louis ;

Rello, Jordi ;

Marshall, John ;

Silva, Eliezer ;

Anzueto, Antonio ;

Martin, Claude D. ;

Moreno, Rui ;

Lipman, Jeffrey ;

Gomersall, Charles ;

Sakr, Yasser ;

Reinhart, Konrad .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 302 (21) :2323-2329