Early life antibiotic use and the risk of asthma and asthma exacerbations in children

被引：87

作者：

Ahmadizar, Fariba ^{[1
]}

Vijverberg, Susanne J. H. ^{[1
,2
]}

Arets, Hubertus G. M. ^{[3
]}

de Boer, Anthonius ^{[1
]}

Turner, Steve ^{[4
]}

Devereux, Graham ^{[4
]}

Arabkhazaeli, Ali ^{[1
]}

Soares, Patricia ^{[5
]}

Mukhopadhyay, Somnath ^{[5
,6
]}

Garssen, Johan ^{[7
,8
]}

Palmer, Colin N. A. ^{[9
]}

de Jongste, Johan C. ^{[10
]}

Jaddoe, Vincent W. V. ^{[11
]}

Duijts, Liesbeth ^{[10
,11
,12
]}

van Meel, Evelien R. ^{[10
,11
]}

Kraneveld, Aletta D. ^{[7
,13
]}

Maitland-van der Zee, Anke H. ^{[1
,2
]}

机构：

[1] Univ Utrecht, Div Pharmacoepidemiol & Clin Pharmacol, UIPS, Fac Sci, Utrecht, Netherlands

[2] Univ Amsterdam, Dept Resp Med, Acad Med Ctr, Amsterdam, Netherlands

[3] Univ Med Ctr Utrecht, Dept Pediat Pulmonol & Allergol, Dept Pediat, Utrecht, Netherlands

[4] Royal Aberdeen Childrens Hosp, Child Hlth, Aberdeen, Scotland

[5] Royal Alexandra Childrens Hosp, Brighton & Sussex Med Sch, Acad Dept Pediat, Brighton, E Sussex, England

[6] Univ Dundee, Ninewells Hosp & Med Sch, Populat Pharmacogenet Grp, Biomed Res Inst, Dundee, Scotland

[7] Univ Utrecht, Div Pharmacol, UIPS, Fac Sci, Utrecht, Netherlands

[8] Nutricia Res, Utrecht, Netherlands

[9] Univ Dundee, Populat Pharmacogenet Grp, Biomed Res Ctr, Dundee, Scotland

[10] Univ Med Ctr, Dept Pediat, Erasmus MC, Div Resp Med & Allergol, Rotterdam, Netherlands

[11] Univ Med Ctr, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands

[12] Univ Med Ctr, Div Neonatol, Erasmus MC, Dept Pediat, Rotterdam, Netherlands

[13] Univ Utrecht, Inst Risk Assessment Sci, Fac Vet Med, Utrecht, Netherlands

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 2017年 / 28卷 / 05期

关键词：

antibiotic; asthma; asthma exacerbations; early life; pediatrics; CHILDHOOD ASTHMA; EXPOSURE; PREGNANCY;

D O I：

10.1111/pai.12725

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

BackgroundThe use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the association between use of antibiotic during the first 3years of life and the risk of developing childhood asthma and the occurrence of asthma exacerbations. MethodsData from four large childhood cohorts were used; two population-based cohorts to study the risk of developing asthma: Generation R (n=7393, The Netherlands) and SEATON (n=891, Scotland, UK), and two asthma cohorts to assess the risk of asthma exacerbations: PACMAN (n=668, The Netherlands) and BREATHE (n=806, Scotland, UK). Odds ratios (ORs) were derived from logistic regression analysis within each database followed by pooling the results using a fixed- or random-effect model. ResultsAntibiotic use in early life was associated with an increased risk of asthma in a meta-analysis of the Generation R and SEATON data (OR: 2.18, 95% CI: 1.04-4.60; I-2: 76.3%). There was no association between antibiotic use in early life and risk of asthma exacerbations later in life in a meta-analysis of the PACMAN and BREATHE data (OR: 0.93, 95% CI: 0.65-1.32; I-2: 0.0%). ConclusionChildren treated with antibiotic in the first 3years of life are more likely to develop asthma, but there is no evidence that the exposure to antibiotic is associated with increased risk of asthma exacerbations.

引用

页码：430 / 437

页数：8

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