Increase of Secondary Processes of Microglial and Astroglial Cells After MPTP-Induced Degeneration in Substantia Nigra Pars Compacta of Non Human Primates

被引：7

作者：

Barcia, Carlos ^{[1
]}

Ros, Carmen M. ^{[1
]}

Carrillo, Maria A. ^{[1
]}

Ros, Francisco ^{[1
]}

Gomez, Aurora ^{[1
]}

de Pablos, Vicente ^{[1
]}

Bautista-Hernandez, Victor ^{[1
]}

Sanchez-Bahillo, Angel ^{[1
]}

Fernandez Villalba, Emiliano ^{[1
]}

Herrero, Maria-Trinidad ^{[1
]}

机构：

[1] Univ Murcia, Clin & Expt Neurosci CIBERNED, Dept Human Anat & Psychobiol, Sch Med, E-30071 Murcia, Spain

来源：

JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT | 2009年 / 73期

关键词：

Astroglia; Glial reaction; Microglia; Neuroinflammation; Parkinson's disease; PARKINSONS-DISEASE; IN-VIVO; IMMUNOLOGICAL SYNAPSES; CEREBROSPINAL-FLUID; HIGH-CAPACITY; BRAIN; CLEARANCE; VECTORS; ANIMALS; BLOOD;

D O I：

10.1007/978-3-211-92660-4_20

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Nigral dopaminergic areas from Parkinsonian patients show an increase of reactive astrocytes and active microglia. The reaction of these two cell types is a clear evidence of inflammatory response associated with dopaminergic cell loss. However, the function of this glial reaction remains unclear. This histological hallmark is also reproduced in induced Parkinsonian animals such as MPTP-treated monkeys. In this work, we analyze with confocal microscopy the number of processes of microglial cells and astrocytes in the SNpc of MPTP-treated monkeys and compare with control animals. We observe that secondary branches from microglia and astrocytes increase in MPTP-treated animals, while the scaffold of primary branches does not change. These results demonstrate that glial reaction in MPTP-treated monkeys is characterized by the emission of new filaments after the dopaminergic degeneration, suggesting that glial cells may increase their scanning progress and modify their microanatomy after dopaminergic injury.

引用

页码：253 / 258

页数：6

共 17 条

[1]

Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure [J].