Tregs in T cell vaccination: exploring the regulation of regulation

被引：57

作者：

Cohen, IR ^{[1
]}

Quintana, FJ ^{[1
]}

Mimran, A ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 09期

关键词：

D O I：

10.1172/JCI200422396

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

T cell vaccination (TCV) activates Tregs of 2 kinds: and-idiotypic (anti-id) and anti-ergotypic (anti-erg). These regulators furnish a useful view of the physiology of T cell regulation of the immune response. Anti-id Tregs recognize specific effector clones by their unique TCR CDR3 peptides; anti-id networks of CD4(+) and CD8(+) Tregs have been described in detail. Here we shall focus on anti-erg T regulators. Anti-erg T cells, unlike anti-id T cells, do not recognize the clonal identity of effector T cells; rather, anti-erg T cells recognize the state of activation of target effector T cells, irrespective of their TCR specificity. We consider several features of anti-erg T cells: their ontogeny, subset markers, and target ergotope molecules; mechanisms by which they regulate other T cells; mechanisms by which they get regulated; and therapeutic prospects for anti-erg upregulation and downregulation.

引用

页码：1227 / 1232

页数：6

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