Microtubule plus-end-tracking proteins: mechanisms and functions

被引：248

作者：

Akhmanova, A

Hoogenraad, CC

机构：

[1] Erasmus MC, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

[2] MIT, Picower Ctr Learning & Mem, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2005年 / 17卷 / 01期

关键词：

D O I：

10.1016/j.ceb.2004.11.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Microtubule plus-end-tracking proteins (+TIPs) are a diverse group of molecules that display dynamic accumulation at the distal ends of growing microtubules. Specific binding to the growing microtubule tip coupled with quick detachment from the older lattice, plus-end-directed transport, and association with other +TIPs can all contribute to this protein localisation. +TIPs act mainly as microtubule-stabilising factors and at the same time often link microtubule ends to various cellular structures, such as the cell cortex or kinetochores. Regulation of the activity of +TIPs has profound effects on the shape of the microtubule network and plays an essential role in cell division, motility and morphogenesis.

引用

收藏

页码：47 / 54

页数：8

相关论文

共 70 条

[1] Control of cell polarity and mitotic spindle positioning in animal cells [J].

Ahringer, J .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (01) :73-81

[2] CLASPs are CLIP-115 and-170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts [J].

Akhmanova, A ;

Hoogenraad, CC ;

Drabek, K ;

Stepanova, T ;

Dortland, B ;

Verkerk, T ;

Vermeulen, W ;

Burgering, BM ;

De Zeeuw, CI ;

Grosveld, F ;

Galjart, N .

CELL, 2001, 104 (06) :923-935

[3] Evidence that an interaction between EB1 and p150Glued is required for the formation and maintenance of a radial microtubule array anchored at the centrosome [J].

Askham, JM ;

Vaughan, KT ;

Goodson, HV ;

Morrison, EE .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (10) :3627-3645

[4] Targeted movement of cell end factors in fission yeast [J].

Browning, H ;

Hackney, DD ;

Nurse, P .

NATURE CELL BIOLOGY, 2003, 5 (09) :812-818

[5] CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast [J].

Brunner, D ;

Nurse, P .

CELL, 2000, 102 (05) :695-704

[6] Characterization of functional domains of human EB1 family proteins [J].

Bu, W ;

Su, LK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (50) :49721-49731

[7] The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules [J].

Busch, KE ;

Brunner, D .

CURRENT BIOLOGY, 2004, 14 (07) :548-559

[8] Tea2p kinesin is involved in spatial microtubule organization by transporting Tip1p on microtubules [J].

Busch, KE ;

Hayles, J ;

Nurse, P ;

Brunner, D .

DEVELOPMENTAL CELL, 2004, 6 (06) :831-843

[9] Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation [J].

Carvalho, P ;

Gupta, ML ;

Hoyt, MA ;

Pellman, D .

DEVELOPMENTAL CELL, 2004, 6 (06) :815-829

[10] Surfing on microtubule ends [J].

Carvalho, P ;

Tirnauer, JS ;

Pellman, D .

TRENDS IN CELL BIOLOGY, 2003, 13 (05) :229-237

← 1 2 3 4 5 6 7 →