Pubertal development and regulation

被引：428

作者：

Abreu, Ana Paula ^{[1
,2
]}

Kaiser, Ursula B. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

LANCET DIABETES & ENDOCRINOLOGY | 2016年 / 4卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CENTRAL PRECOCIOUS PUBERTY; GENOME-WIDE ASSOCIATION; FAMILIAL HYPOGONADOTROPIC HYPOGONADISM; SECONDARY SEXUAL CHARACTERISTICS; NUTRITION EXAMINATION SURVEY; PITUITARY-GONADAL AXIS; KISS1; GENE-EXPRESSION; GROWTH-FACTOR-I; LUTEINIZING-HORMONE; NEUROKININ B;

D O I：

10.1016/S2213-8587(15)00418-0

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Puberty marks the end of childhood and is a period when individuals undergo physiological and psychological changes to achieve sexual maturation and fertility. The hypothalamic-pituitary-gonadal axis controls puberty and reproduction and is tightly regulated by a complex network of excitatory and inhibitory factors. This axis is active in the embryonic and early postnatal stages of life and is subsequently restrained during childhood, and its reactivation culminates in puberty initiation. The mechanisms underlying this reactivation are not completely known. The age of puberty onset varies between individuals and the timing of puberty initiation is associated with several health outcomes in adult life. In this Series paper, we discuss pubertal markers, epidemiological trends of puberty initiation over time, and the mechanisms whereby genetic, metabolic, and other factors control secretion of gonadotropin-releasing hormone to determine initiation of puberty.

引用

页码：254 / 264

页数：11

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