Haemodynamic and electrocardiographic consequences of severe nicorandil toxicity

被引:4
作者
Greenwood, JP
Malik, I
Jennings, P
Stevenson, RN
机构
[1] Gen Infirm, Yorkshire Heart Ctr, Acad Unit Cardiovasc Med, Leeds LS1 3EX, W Yorkshire, England
[2] Univ Liverpool, Aintree Hosp, Liverpool L69 3BX, Merseyside, England
[3] Huddersfield Royal Infirm, Huddersfield, W Yorkshire, England
关键词
D O I
10.1136/emj.20.1.98
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
A 35 year old woman was admitted to the emergency department two hours after ingesting 60×20 mg tablets of nicorandil, total 1.2 g. The dominant feature of icorandil toxicity was profound peripheral vasodilatation associated with coronary hypoperfusion. Despite widespread electrocardiographic signs of myocardial ischaemia, there was no evidence of myocardial damage and no serious cardiac arrhythmia. Volume loading and pressor support proved to be an effective treatment strategy.
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收藏
页码:98 / 100
页数:3
相关论文
共 11 条
[1]   VASODILATORY EFFECT OF NICORANDIL ON CORONARY ARTERIAL MICROVESSELS - ITS DEPENDENCY ON VESSEL SIZE AND THE INVOLVEMENT OF THE ATP-SENSITIVE POTASSIUM CHANNELS [J].
AKAI, K ;
WANG, Y ;
SATO, K ;
SEKIGUCHI, N ;
SUGIMURA, A ;
KUMAGAI, T ;
KOMARU, T ;
KANATSUKA, H ;
SHIRATO, K .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1995, 26 (04) :541-547
[2]   Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial [J].
Dargie, HJ ;
Ford, I ;
Fox, KM ;
Hillis, WS .
LANCET, 2002, 359 (9314) :1269-1275
[3]  
Dunn N, 1999, PHARMACOEPIDEM DR S, V8, P197, DOI 10.1002/(SICI)1099-1557(199905/06)8:3<197::AID-PDS422>3.0.CO
[4]  
2-T
[5]   NICORANDIL - A REVIEW OF ITS PHARMACOLOGY AND THERAPEUTIC EFFICACY IN ANGINA-PECTORIS [J].
FRAMPTON, J ;
BUCKLEY, MM ;
FITTON, A .
DRUGS, 1992, 44 (04) :625-655
[6]   Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction [J].
Ito, H ;
Taniyama, Y ;
Iwakura, K ;
Nishikawa, N ;
Masuyama, T ;
Kuzuya, T ;
Hori, M ;
Higashino, Y ;
Fujii, K ;
Minamino, T .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (03) :654-660
[7]   Effects of nicorandil, a potassium channel opener, on idiopathic ventricular tachycardia [J].
Kobayashi, Y ;
Miyata, A ;
Tanno, K ;
Kikushima, S ;
Baba, T ;
Katagiri, T .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (05) :1377-1383
[8]  
KRUMENACKER M, 1992, J CARDIOVASC PHARM, V20, pS93
[9]   Cardioprotection by opening of the KATP channel in unstable angina -: Is this a clinical manifestation of myocardial preconditioning?: Results of a randomized study with nicorandil [J].
Patel, DJ ;
Purcell, HJ ;
F'ox, KM .
EUROPEAN HEART JOURNAL, 1999, 20 (01) :51-57
[10]  
PURCELL H, 1996, CARDIOVASCULAR DRUG, P1638