Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation

被引：132

作者：

Schmidt-Weber, CB ^{[1
]}

Blaser, K ^{[1
]}

机构：

[1] Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.coi.2004.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Transforming growth factor-beta (TGF-beta) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-beta in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-beta in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-beta; however, TGF-beta-mediated tissue remodelling can be a serious complication in such diseases.

引用

页码：709 / 716

页数：8

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