Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801

被引：61

作者：

Fumagalli, F

Molteni, R

Bedogni, F

Gennarelli, M

Perez, J

Racagni, G

Riva, MA

机构：

[1] Univ Milan, Dept Pharmacol Sci, Ctr Neuropharmacol, I-20133 Milan, Italy

[2] Univ Milan, Dept Pharmacol Sci, CEND, I-20133 Milan, Italy

[3] IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy

[4] Univ Brescia, Dept Biomed Sci & Technol, Div Biol & Genet, I-25121 Brescia, Italy

来源：

NEUROREPORT | 2004年 / 15卷 / 13期

关键词：

conventional and atypical antipsychotics; haloperidol; neurotrophic factors; quetiapine; rat hippocampus;

D O I：

10.1097/00001756-200409150-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.

引用

页码：2109 / 2112

页数：4

共 18 条

[1]

Angelucci F, 2000, J NEUROSCI RES, V60, P783, DOI 10.1002/1097-4547(20000615)60:6<783::AID-JNR11>3.0.CO

[2]

2-M

[3] Differential effects of typical and atypical antipsychotic drugs on striosome and matrix compartments of the striatum [J].