Glycosphingolipids in microdomain formation and their spatial organization

被引：54

作者：

Gupta, Garima ^{[2
]}

Surolia, Avadhesha ^{[1
,2
]}

机构：

[1] Natl Inst Immunol, New Delhi 110067, India

[2] Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India

来源：

FEBS LETTERS | 2010年 / 584卷 / 09期

关键词：

Glycosphingolipid; Sphingomyelin; Ganglioside; Sulfatide; Liquid-disordered phase; Microdomain; PLASMA-MEMBRANE; DOMAIN FORMATION; LIPID-BILAYERS; RICINUS-COMMUNIS; GANGLIOSIDE GM1; MODEL MEMBRANES; CHOLESTEROL; LECTIN; FLUID; SPHINGOLIPIDS;

D O I：

10.1016/j.febslet.2009.11.070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasma membranes regulate the influx and efflux of molecules across themselves and are also responsible for primary signal transduction between cells or within the same cell. Presence of lateral heterogeneity and the ability of reorganization are essential requirements for effective functioning of biomembranes. Lipid rafts are small, heterogeneous, dynamic domains enriched in glycosphingolipids, sphingomyelin and cholesterol, and profoundly influence membrane organization. Glycosphingolipids are inclined towards formation of liquid-ordered phases in membranes, both with and without cholesterol; they are therefore prime players in domain formation. Here, we discuss the role of glycosphingolipids in microdomain formation and their spatial organization within these rafts. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1634 / 1641

页数：8

共 61 条

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