Photochemically-activated probes of protein-protein interactions

被引：21

作者：

Nandy, Sandip K. ^{[1
]}

Agnes, Richard S. ^{[1
]}

Lawrence, David S. ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 12期

关键词：

D O I：

10.1021/ol070238t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The activity of light-activatable ("caged") compounds can be temporally and spatially controlled, thereby providing a means to interrogate intracellular biochemical pathways as a function of time and space. Nearly all caged peptides contain photocleavable groups positioned on the side chains of key residues. We describe an alternative active site targeted strategy that disrupts the interaction between the protein target (SH2 domain, kinase, and proteinase) and a critical amide NH moiety of the peptide probe.

引用

页码：2249 / 2252

页数：4

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