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Rotavirus vaccines: recent developments and future considerations

被引：119
作者：
Angel, Juana
Franco, Manuel A.
Greenberg, Harry B.
机构：
[1] Pontificia Univ Javeriana, Inst Genet Humana, Bogota, Colombia
[2] Stanford Univ, Sch Med, Stanford, CA 94305 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 07期
关键词：
D O I：
10.1038/nrmicro1692
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Two new vaccines have recently been shown to be safe and effective in protecting young children against severe rotavirus gastroenteritis. Although both vaccines are now marketed worldwide, it is likely that improvements to these vaccines and/or the development of future generations of rotavirus vaccines will be desirable. This Review addresses recent advances in our knowledge of rotavirus, the host immune response to rotavirus infection and the efficacy and safety of the new vaccines that will be helpful for improving the existing rotavirus vaccines, or developing new rotavirus vaccines in the future.
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页码：529 / U18
页数：12
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