The purinergic calcium channels P2X1,2,5,7 are down-regulated while P2X3,4,6 are up-regulated during apoptosis in the ageing rat prostate

被引：23

作者：

Slater, M ^{[1
]}

Barden, JA ^{[1
]}

Murphy, CR ^{[1
]}

机构：

[1] Univ Sydney, Dept Anat & Histol, Sydney, NSW 2006, Australia

来源：

HISTOCHEMICAL JOURNAL | 2000年 / 32卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1023/A:1004110529753

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Subtype-specific antibodies were used to measure purinergic (P2X) receptor expression in the rat prostate. In mature Wistar rats, apoptosis and expression of P2X(1), P2X(2), P2X(5) and P2X(7) subtypes were all significantly decreased compared with the levels found in immature rat prostates. Accompanying this age-related reduction in purinergic calcium channel expression was a reduction in epithelial and stromal calcium as well as the calcium-regulating hormone stanniocalcin. In contrast, expression of P2X(3), P2X(4) and P2X(6) increased with age. These results suggest that distinct changes in P2X subtype expression accompany apoptosis in the rat prostate.

引用

页码：571 / 580

页数：10

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