Enhanced transdermal delivery of atenolol from the ethylene-vinyl acetate matrix

被引：24

作者：

Cho, CW

Shin, SC

机构：

[1] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea

[2] CJ Corp, R&D Ctr Pharmaceut, Inchon 467812, Gyonggido, South Korea

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2004年 / 287卷 / 1-2期

关键词：

atenolol; ethylene-vinyl acetate; transdermal delivery; penetration enhancer; matrix;

D O I：

10.1016/j.ijpharm.2004.08.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To enhance transdermal delivery of atenolol, ethylene-vinyl acetate (EVA) matrix of drug containing penetration enhancer was fabricated. Effect of penetration enhancer on the permeation of atenolol through the excised rat skin was studied. Penetrating enhancers showed the increased flux probably due to the enhancing effect on the skin barrier, the stratum corneum. Among enhancers used such as glycols, fatty acids and non-ionic surfactants, polyoxyethylene 2-oleyl ether showed the best enhancement. For the controlling transdermal delivery of atenolol, the application of EVA matrix containing permeation enhancer could be useful in the development of transdermal drug delivery system. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：67 / 71

页数：5

共 23 条

[1] CONTRIBUTIONS OF DRUG SOLUBILIZATION, PARTITIONING, BARRIER DISRUPTION, AND SOLVENT PERMEATION TO THE ENHANCEMENT OF SKIN PERMEATION OF VARIOUS COMPOUNDS WITH FATTY-ACIDS AND AMINES [J].